NCT06418074Completed
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Patients With Essential Hypertension
Source: ClinicalTrials.gov · Last updated 10 Dec 2025
Brief summary (registry, in English)
This is a randomized, placebo-controlled, double-blinded crossover design. Nineteen patients with essential hypertension will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid. After a period of 5-days treatment, effect variables will be measured (experiment day 1). After a washout period of 14 days, the subjects are crossed over to a similar treatment period with the other treatment. The study is terminated by measuring effect variables after the second treatment period (experiment day 2).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 6 May 2024
- Start date
- 11 Sept 2024
- Primary completion date
- 19 Jun 2025
- Lead sponsor
- Gødstrup Hospital
- Diseases
- High blood pressure
- NCT number
- NCT06418074
What you commit to
- Study type: Interventional
- Participants enrolled: 20
- From 11 Sept 2024 to the primary completion date, 19 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Daily use of prescription drugs (expect for contraceptives)
- Alcohol or drug abuse
- Treatment with immunosuppressants or SGLT2-inhibitors
Other illness
- Diabetes type 1 or 2
- Heart Failure
- Liver disease
- Malignant disease
- Recent acute myocardial infarction (AMI), apoplexia/transient ischemic attack (TIA) (within 12 months of inclusion)
Other
- Pregnancy or breast feeding
- Periodic fasting
- Routinely intake of ketogenic diet
Who the study is looking for
- Essential hypertension (treatment with maximum 2 antihypertensive drugs)
- eGFR \> 60ml/min
- BMI \< 35 kg/m2
- Urine Albumin Creatinin Ratio (UACR) \< 300mg/g
- Safe contraception if women in childbearing age
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University Clinic in Nephrology and Hypertension, Gødstrup Region Hospital Coordinator of this site? Confirm its status | Herning | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.