NCT06420726Completed
Resistance Exercise and Creatine in Colorectal Cancer
The Feasibility and Acceptability of Resistance Training and Creatine Supplementation to Promote Physical Function in Sarcopenic Colorectal Cancer Survivors
Source: ClinicalTrials.gov · Last updated 5 Jun 2026
Brief summary (registry, in English)
Low skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients. This condition arises from a combination of factors such as aging, inactivity, treatment side effects, malnutrition, tumor burden, and inflammation. Given this complexity, singular interventions may not be sufficient to address low muscle mass in this group. Creatine monohydrate, a compound vital for energy during exercise, has been extensively researched and proven safe and effective across various demographics, including older adults and clinical populations. Studies show that creatine enhances benefits from resistance training, indicating potential to counter muscle mass and function decline post-cancer treatment. This study aims to assess the feasibilty of combining creatine supplementation with resistance training versus resistance training alone in colorectal cancer survivors treated with chemotherapy. A randomized controlled pilot trial will compare a 10-week program of resistance exercise plus creatine (EXSUPP) with resistance exercise alone (EXPLA), each with 20 participants.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 27 (actual)
- First submitted
- 14 May 2024
- Start date
- 1 Sept 2023
- Primary completion date
- 15 Sept 2025
- Lead sponsor
- University of South Carolina
- Diseases
- Colorectal cancer
- NCT number
- NCT06420726
What you commit to
- Study type: Interventional
- Participants enrolled: 27
- From 1 Sept 2023 to the primary completion date, 15 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- are receiving active treatment for their cancer;
- are currently taking supplements containing creatine for 4 weeks prior to the start of the RCT, or
- are receiving medications that might alter body composition (metformin, corticosteroids etc.).
Other illness
- had a musculoskeletal, cardiovascular, neurological, or psychological condition that precluded participation in RET;
Other
- had been participating in structured RET two or more times per week for the past 6 months
Who the study is looking for
- Individuals ≥12 months post treatment with chemotherapy for colorectal cancer
- \>18 years
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of South Carolina Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.