NCT06421987Recruiting
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors. Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. . Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity. CONTROLS Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 1 May 2024
- Start date
- 6 May 2024
- Primary completion date
- Dec 2026
- Lead sponsor
- St. Jude Children's Research Hospital
- Diseases
- Hodgkin lymphoma
- NCT number
- NCT06421987
What you commit to
- Study type: Observational
- Planned participants: 100
- From 6 May 2024 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of cranial or total-body irradiation therapy.
- History of intrathecal or high dose intravenous antimetabolite therapy.
- History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.
Other
- HL Survivors
Who the study is looking for
- HL Survivors
- Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH.
- \<21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy.
- SJLIFE or ACT/SJLIFE participants
- English language proficiency.
- Community Controls
- SJLIFE control.
- ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.