NCT06424015Recruiting
Insulin and Insulin Pulses During Fasting
Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 13 May 2024
- Start date
- 15 Sept 2024
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- Mayo Clinic
- Diseases
- Type 2 diabetes
- NCT number
- NCT06424015
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Sept 2024 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
Other illness
- Active systemic illness or malignancy.
- Symptomatic macrovascular or microvascular disease.
Lab values
- HbA1c \> 6.5%
- Use of any glucose-lowering agents including metformin or sulfonylureas.
Other
- BMI ≥ 35 Kg/M2
- For female subjects: positive pregnancy test at the time of enrollment or study
- Hematocrit \< 35%
Who the study is looking for
- people with normal or impaired fasting glucose and normal or impaired glucose tolerance
Age in the registry: 25 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.