NCT06424106Recruiting
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 13 May 2024
- Start date
- 1 Apr 2025
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- Mayo Clinic
- Diseases
- Type 2 diabetes
- NCT number
- NCT06424106
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Apr 2025 to the primary completion date, 1 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
Other illness
- Active systemic illness or malignancy.
- Symptomatic macrovascular or microvascular disease.
Lab values
- HbA1c less than 6.5%
- Use of any glucose-lowering agents including metformin or sulfonylureas.
Other
- For female subjects: positive pregnancy test at the time of enrollment or study
Who the study is looking for
- Individuals with normal or impaired fasting glucose and normal or impaired glucose tolerance
Age in the registry: 25 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.