NCT06424756RecruitingPhase 2
Effects of an Antioxidant Supplement on Blood Vessel Health
Role of Mitochondria-derived Oxidative Stress on Microvascular Endothelial Function in Healthy Non-Hispanic Black and White Adults
Source: ClinicalTrials.gov · Last updated 9 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 16 May 2024
- Start date
- 1 Jul 2024
- Primary completion date
- 31 Mar 2030
- Lead sponsor
- University of Georgia
- Diseases
- High blood pressure
- NCT number
- NCT06424756
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 1 Jul 2024 to the primary completion date, 31 Mar 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of illegal/recreational drugs
- Any current medications which could conceivably alter the cardiovascular control or responses
Other illness
- Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)
- Known skin allergies to latex or adhesives
- Generalized kidney disease
- Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital/phenytoin, orlistat or pyrimethamine
- Diagnosed or suspected metabolic or cardiovascular disease
- History of skin or other cancers
- Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.
Lab values
- Diagnosed or suspected diabetes (HbA1c ≥6.0)
Other
- Smoking and/or use of nicotine-containing products within the past year
- Current pregnancy or breastfeeding
Who the study is looking for
- Self-identify as either non-Hispanic Black or non-Hispanic White.
- Men and women 18-75 years old.
- Non-hypertensive (systolic blood pressure \[SBP\]\<130 and diastolic blood pressure \[DBP\] \<85 mmHg).
- Have low density lipoprotein cholesterol \<150mg/dl.
- Have HbA1C \<6.0%.
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ramsey Student Center, University of Georgia Coordinator of this site? Confirm its status | Athens | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.