NCT06427018Recruiting
Expressions of Ezrin and Pip5k1α Proteins in Airway Smooth Muscle of Asthmatic Patients
Assessing the Expressions of Ezrin, Phosphorylated Ezrin, and Pip5k1α in the Airway Smooth Muscle of Asthmatic Patient
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
Asthma, a prevalent chronic respiratory affliction, significantly impinges upon the quality of life for affected individuals. Timely and appropriate diagnostic measures, coupled with efficacious therapeutic interventions, are paramount in mitigating exacerbations of symptoms and enhancing the life quality of patients. Ezrin plays an important role in maintaining cell morphology, cell migration, cell adhesion and polarisation, but Ezrin expression in airway smooth muscle remains unclear. Pip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole. Therefore, further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 19 May 2024
- Start date
- 28 May 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Lei-Miao Yin
- Diseases
- Asthma
- NCT number
- NCT06427018
What you commit to
- Study type: Observational
- Planned participants: 120
- From 28 May 2024 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Paraffin sections of lung tissue from patients who have been diagnosed with COPD;
- Other situations where the researcher deems it inappropriate to participate in this study.
Who the study is looking for
- Lung tissue samples;
- The samples come from patients aged 18-70 years old, regardless of gender, who underwent lung tissue sampling for surgical indications during treatment;
- Paraffin sections of lung tissue from patients diagnosed with bronchial asthma, including tracheal smooth muscle;
- Paraffin sections of lung tissue from non-asthma patients, including tracheal smooth muscle.
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yueyang Hospital, Shanghai University of Traditional Chinese Medicine Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.