NCT06428838Enrolling by invitationPhase 3
Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Context
Eptinezumab as an Adjunct to Standard of Care for MIGRANE in an Acute EmeRgency Context (Migraine ERase Study)
Source: ClinicalTrials.gov · Last updated 30 Sept 2026
Brief summary (registry, in English)
The purpose of the study is to investigate how a medication called eptinezumab (Vyepti) given to patients in the Emergency Department (ED) might help prevent migraines from happening again. The results of this study may help inform better ways to manage patients with migraines in the ED. Eptinezumab is currently approved by Health Canada for the preventive treatment of migraine, but its short-term effectiveness in the ED context is unknown. Unlike other migraine treatments used in the ED, eptinezumab can rapidly interrupt the migraine process, potentially also preventing migraine from coming back in the short term. Most patients with a diagnosis of migraine have no access to preventative therapies. This study will be able to provide access to preventative therapy at the earliest stages of a migraine attack. Administering this medication in the ED may stop the attack more effectively compared to current therapies. This study wants to see if eptinezumab could help stop migraines from coming back after individuals have been treated in the ED. The study will also explore whether eptinezumab could reduce how often individuals with migraine might need to come back to the ED, what other medications they might need alongside eptinezumab, and how they feel overall.
- Status (registry)
- Enrolling by invitation
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 102 (estimated)
- First submitted
- 16 May 2024
- Start date
- 5 May 2025
- Primary completion date
- Mar 2028
- Lead sponsor
- Dr George Medvedev
- Diseases
- Migraine
- NCT number
- NCT06428838
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 102
- From 5 May 2025 to the primary completion date, Mar 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently enrolled in another investigational drug trial
- Currently on anti-CGRP therapy with monoclonal antibodies
Other illness
- Secondary headaches caused by an injury or underlying illness, such as a concussion, bleeding in the brain, an infection or a brain tumor
- Current or history of severe cardiovascular disease or renal dysfunction
- A systemic condition in the stage of active treatment (vasculitis, etc.)
- Any other condition which, in the opinion of the Investigator, would exclude the participant due to reasons of safety or data integrity
- Hypersensitivity to the active substance or to any of the excipients
Other
- Pregnant or at risk of becoming pregnant (absent contraception)
- Dosed with eptinezumab within the past 3 months
- Currently involved in active litigation
Who the study is looking for
- Adults between the ages of 19-75 with a history of migraines, as established at the time of presentation to the ED or known from the patient's chart;
- Presenting to the emergency department with a migraine that meets ICHD-3 migraine headache criteria;
- Provided signed informed consent;
- Sufficient literacy and cognitive capacity to understand and complete patient self-rated questionnaires in English.
Age in the registry: 19 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Columbian Hospital Coordinator of this site? Confirm its status | New Westminster | Canada | Unknown status |
| Surrey Memorial Hospital Coordinator of this site? Confirm its status | Surrey | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.