NCT06432972Recruiting
Accelerated Pulmonary Rehabilitation in the Preoperative Period
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with or without surgical resection will be recruited from the University of Vermont Medical Center (UVMMC)pulmonary, cardiothoracic surgery, and Lung Multidisciplinary Clinic (LMDC). All patients will be enrolled in prehab and offered smoking cessation therapy. The acceptability and feasibility of this intervention will be measured by percent enrollment in study, attendance, barriers to completion, and monitoring of adverse events. The effect of prehab will be measured by traditional metrics, including fitness, respiratory symptoms, and depression scale. Research outcomes will be measured by smoking habits, anxiety, and surgical complications. Investigators estimate that 20 participants over a two-year period will be sufficient to measure the safety and feasibility of this study. Investigators aim to enroll, on average, 2 participants per month in order to complete this study in a timely fashion. Participants will be enrolled in prehab on a rolling basis, as to not delay surgical timeline.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 13 May 2024
- Start date
- 2 Jan 2024
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- University of Vermont
- Diseases
- COPD, Lung cancer
- NCT number
- NCT06432972
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 2 Jan 2024 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unable to safely participate in PR due to unstable cardiac disease, unstable peripheral vascular disease, musculoskeletal disease that would prevent exercise, significant psychiatric or neurocognitive disease that would limit ability to exercise safely in a group setting as determined by the study physician and/or treatment physicians
- Any other condition in the opinion of the investigator/study physician and or treatment physicians that would jeopardize patient safety or integrity of research results
Other
- Inability to consistently attend PR during treatment
- Pregnancy, per patient self-report
- Active or recent participation in another clinical trial that, in the opinion of the investigator would impact outcomes measured in this study
Who the study is looking for
- Age 18 years or older
- Lung nodule that is deemed highly suspicious for lung cancer based on: nodule characteristics, risk factors, CT-PET avidity, previous biopsy results, and assessment by physicians specializing in lung cancers
- Eligible for treatment
- Current cigarette smoking ≥5 cigarettes per day
- Willing to attempt smoking cessation during prehab period
- Willing to take nicotine replacement therapy (NRT) and varenicline
- Able to attend PR at UVMMC for 2, one-hour sequential sessions for a total of 16 sessions over 8 days during treatment
- Willing and able to provide informed consent; ability determined by study physician and/or LMDC treatment physicians
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Vermont Medical Center Coordinator of this site? Confirm its status | Burlington | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.