NCT06437964Completed
Prophylactic Antibiotics in Endoscopic Secondary Prevention of Gastroesophageal Variceal Bleeding
The Use of Prophylactic Antibiotics in the Endoscopic Secondary Prevention of Cirrhotic Patients With Gastroesophageal Variceal Bleeding
Source: ClinicalTrials.gov · Last updated 27 May 2026
Brief summary (registry, in English)
Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this non-inferiority trial, we are aimed to evaluate whether prophylactic antibiotics are essential in the endoscopic secondary prevention of cirrhotic patients with gastroesophageal variceal bleeding.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 226 (actual)
- First submitted
- 26 May 2024
- Start date
- 25 May 2024
- Primary completion date
- 15 Jan 2026
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Diseases
- High blood pressure
- NCT number
- NCT06437964
What you commit to
- Study type: Interventional
- Participants enrolled: 226
- From 25 May 2024 to the primary completion date, 15 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Allergy to cephalosporin.
- Already have infection or fever (body temperature \> 37.5 ℃) before signing the informed consent form.
- Withdraw Criteria:
- Transferred to other department for additional treatment after the endoscopic operation (Surgical department for malignant tumor, Interventional radiology department for splenic embolism or transjugular intrahepatic portosystemic shunt, etc.).
- The patient suffered massive bleeding during the endoscopy, and cephalosporin was given immediately after being sent back to the ward.
Lab values
- Have granulocyte deficiency (neutrophil count ≤ 0.5 \* 10 \^ 9/L, or white blood cell count ≤ 1.0 \* 10 \^ 9/L) before the endoscopic operation.
Age
- Age \<18, or ≥81.
Other
- The patient is unwilling to sign the informed consent form.
- The patient turned back after signing the consent, and before the endoscopic operation.
- Have fever (body temperature \> 37.5 ℃) after signing the consent, and before the endoscopic operation.
Who the study is looking for
- Cirrhotic patients having a history of gastroesophageal variceal bleeding are readmitted for endoscopic secondary prevention.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.