NCT06439355Recruiting
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- First submitted
- 28 May 2024
- Start date
- 27 May 2024
- Primary completion date
- May 2027
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Diseases
- Lewy body dementia, Parkinson disease
- NCT number
- NCT06439355
What you commit to
- Study type: Interventional
- Planned participants: 66
- From 27 May 2024 to the primary completion date, May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Known infection with COVID-19 in the 6 months prior to inclusion
- Taking medication (in progress at the time of the study) that interferes with gustation
Other
- Non-affiliated to national health insurance
- Person under legal protection (curatorship, guardianship)
- Person subject to a court order
- Pregnant, parturient or breast-feeding women
- Major unable to give consent
- MMSE score \< 15 and/or MoCA \< 10
- Active smoker (\> 4 cigarettes per day on a regular basis)
- Subject with pacemaker (contraindication for bioelectrical impedancemetry)
- Diabetic (type 1 or type 2)
Who the study is looking for
- Healthy volunteers:
- Person who has given written consent
- Adult
- Enrolled in the national register of healthy volunteers
- Fasting \> 2 hours before PEG measurement
- Body Mass Index (BMI) \< 30 kg/m².
- No cognitive complaints and normal neurological assessment
- Patients with idiopathic Parkinson's disease:
- Person who has given written consent
- Adult
- Fasting \> 2 hours before PEG measurement
- Body Mass Index (BMI) \< 30 kg/m².
- Diagnostic criteria for established or probable IPD
- Patients with Lewy body disease:
- Person who has given written consent
- Adult
- Fasting \> 2 hours prior to PEG measurement
- Body Mass Index (BMI) \< 30 kg/m².
- Diagnostic criteria for probable or possible LBD
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu Dijon Bourgogne Coordinator of this site? Confirm its status | Dijon | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.