NCT06439745Completed
More Than 50% of Unifocal cN0 T1b/Small T2 Papillary Thyroid Carcinoma May Require Completion Thyroidectomy if Nodal Status is Evaluated
More Than 50% of the Patients With Clinically Unifocal T1b/Small T2 Node Negative Papillary Thyroid Carcinoma Scheduled for Thyroid Lobectomy May Require Completion Thyroidectomy if the Nodal Status is Evaluated
Source: ClinicalTrials.gov · Last updated 2 Sept 2025
Brief summary (registry, in English)
In absence of nodal metastases or aggressive features, thyroid lobectomy (TL) should be preferred over total thyroidectomy (TT) for small unifocal papillary thyroid carcinoma (PTC). However, occult, despite non-microscopic (\>2 mm), nodal metastases may be present in clinically node-negative (cN0) PTCs. Among 4216 thyroidectomies for malignancy (2014-2023), 110 (2.6%) TL plus ipsilateral central neck dissection (I-CND) were scheduled for unifocal cT1b/small cT2 (\<3 cm) cN0 PTCs. Nodes frozen section examination (FSE) was performed: when positive, completion thyroidectomy (CT) was accomplished during the same procedure. In presence of aggressive pathologic features, CT was suggested within 6 months from index operation.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 314 (actual)
- First submitted
- 7 Mar 2024
- Start date
- Sept 2014
- Primary completion date
- Sept 2023
- Lead sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Diseases
- Thyroid cancer
- NCT number
- NCT06439745
What you commit to
- Study type: Observational
- Participants enrolled: 314
- From Sept 2014 to the primary completion date, Sept 2023
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prior head or neck irradiation
Other illness
- family history of thyroid carcinoma
Age
- age \< 18
Other
- clinical evidence of multifocality
- extrathyroidal extension or LN metastases
- follow-up \< 6 months.
Who the study is looking for
- age\>18
- classic papillary carcinoma and variants
- clinically unifocal and intrathyroidal PTC
- clinical tumor size \>1 cm and ≤3 cm
- no clinical evidence of LN involvement
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.