NCT06439875Completed
Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.
Effects of the Association of L-arginine and Liposomal Vitamin C on Fatigue in COPD Patients With Chronic Respiratory Failure After Rehabilitation Intervention
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
The hypothesis that is being tested is that the supplementation of L-arginine plus Vitamin C to multidisciplinary pulmonary rehabilitation (PR) in patients with a previous diagnosis of chronic obstructive pulmonary disease (COPD) and chronic respiratory failure can have a favorable influence on fatigue and on clinical indicators related to endothelial function, potentially mitigating the cardiovascular (CV) disease burden in this clinical context.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 101 (actual)
- First submitted
- 28 May 2024
- Start date
- 16 Jul 2024
- Primary completion date
- 16 Feb 2026
- Lead sponsor
- Istituti Clinici Scientifici Maugeri SpA
- Diseases
- COPD
- NCT number
- NCT06439875
What you commit to
- Study type: Interventional
- Participants enrolled: 101
- From 16 Jul 2024 to the primary completion date, 16 Feb 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- severe acute exacerbations in the 3 months before enrolment;
- any prior or current medical problem that would limit the subject participation
Other illness
- lung restrictive diseases;
- primitive pulmonary hypertension;
- orthopaedic clinical conditions interfering with exercise;
- coronary heart disease;
- major cardiac arrhythmias;
- neuromuscular diseases;
Lab values
- cardiac failure with reduced ejection fraction;
Other
- consuming any ergogenic supplement in the last 2 months;
- clinical instability (pH inferior to 7.35, hemodynamic instability, tachypnea at rest);
- recent lung thromboembolic events;
- mini mental state examination (MMSE) \<24;
Who the study is looking for
- COPD patients of both sexes complicated by respiratory failure (PaO2 inferior to 60 mmHg while breathing room air)
- aged between 40 and 90 years selected from the inpatient/outpatient population admitted to perform a PR program in 12 Italian rehabilitation hospitals.
Age in the registry: 40 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istituti Clinici Scientifici Maugeri IRCCS Coordinator of this site? Confirm its status | Bari | Italy | Unknown status |
| Istituti Clinici Scientifici Maugeri IRCCS Coordinator of this site? Confirm its status | Lumezzane | Italy | Unknown status |
| Istituti Clinici Scientifici Maugeri IRCCS Coordinator of this site? Confirm its status | Telese Terme | Italy | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.