NCT06441643CompletedPhase 2
Next Generation Rocklatan
A Phase II, Prospective, Two-Stage, Double-Masked, Randomized, Multi-Center, Controlled, Dose-Response Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-17043 and PG043 (AR-17043/Latanoprost) Ophthalmic Solutions in Subjects With Elevated Intraocular Pressure
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
The purpose of this two-stage clinical trial is to assess the safety and hypotensive efficacy of AR-17043 and PG043 ophthalmic solutions in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 426 (actual)
- First submitted
- 29 May 2024
- Start date
- 4 Sept 2024
- Primary completion date
- 14 Nov 2025
- Lead sponsor
- Alcon Research
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT06441643
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 426
- From 4 Sept 2024 to the primary completion date, 14 Nov 2025
- 12 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Stage 1 Key Inclusion Criteria;
- Diagnosis of OAG or OHT in both eyes.
- High unmedicated IOP measurements in the study eye as specified in the protocol.
- Corrected visual acuity equal to or better than +1.0 logMAR (Snellen equivalent equal to or better than 20/200) in the study eye.
- Other protocol-specified inclusion criteria may apply.
- Stage 2 Key Inclusion Criteria:
- Diagnosis of OAG or OHT in both eyes.
- High unmedicated IOP measurements in the study eye as specified in the protocol.
- Corrected visual acuity equal to or better than +0.7 logMAR (Snellen equivalent equal to or better than 20/100) in the study eye.
- Other protocol-specified inclusion criteria may apply.
- Stage 1 and Stage 2 Key Exclusion Criteria:
- Current use of more than 2 ocular hypotensive medications within 30 days (either eye).
- Intraocular pressure greater than 36 millimeters mercury (mmHg) at Screening.
- Glaucoma other than OAG.
- Previous glaucoma surgery.
- Any abnormality preventing reliable measurements.
- Unable to demonstrate proper eyedrop instillation.
- Other protocol-specified exclusion criteria may apply.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Scott & Christie and Associates, PC Coordinator of this site? Confirm its status | Cranberry Township | United States | Unknown status |
| Eye Center of Northern Colorado, PC Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
| Orange County Ophthalmology Medical Group Coordinator of this site? Confirm its status | Garden Grove | United States | Unknown status |
| United medical research institute Coordinator of this site? Confirm its status | Inglewood | United States | Unknown status |
| Piedmont Eye Center Coordinator of this site? Confirm its status | Lynchburg | United States | Unknown status |
| University Eye Specialists Coordinator of this site? Confirm its status | Maryville | United States | Unknown status |
| Total Eye Care, PA Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Eye Research Foundation Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| North Bay Eye Associates Coordinator of this site? Confirm its status | Petaluma | United States | Unknown status |
| Rochester Ophthalmological Group Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Coastal Research Associates Coordinator of this site? Confirm its status | Roswell | United States | Unknown status |
| James D. Branch Ophthalmology Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.