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NCT06443684Active, not recruiting

A Study of Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC

Prospective, Observational Study of Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC

Source: ClinicalTrials.gov · Last updated 17 Jun 2026

Brief summary (registry, in English)

The goal of this prospective, observational study is to explore the value of dynamic monitoring of minimal residual lesions in driver mutated stage III NSCLC for disease recurrence and prognosis assessment. The main question it aims to answer is: 1\) Whether MRD(Minimal residual disease) status can predict recurrence events in stage III driven-mutant NSCLC in advance

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
305 (estimated)
First submitted
30 May 2024
Start date
8 May 2023
Primary completion date
7 Dec 2026
Lead sponsor
Shanghai Chest Hospital
Diseases
Lung cancer
NCT number
NCT06443684

What you commit to

  • Study type: Observational
  • Planned participants: 305
  • From 8 May 2023 to the primary completion date, 7 Dec 2026
  • 14 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Patients with other malignancies within 5 years
  • According to the investigator, the patient also had other diseases that may affect the follow-up and short-term survival

Lab values

  • The subject had other factors that may lead to the termination of the study, such as other serious diseases (including mental illness), serious laboratory abnormalities, and family or social factors that affected the safety of the subject, or the collection of data and samples

Who the study is looking for

  • Patients with stage III non-small cell lung cancer were confirmed by imaging and histological biopsy
  • Age≥ 18
  • ECOG PS:0-1
  • Tumor molecular testing by EBUS or biopsy confirmed positive for one or more of the following driver genes:EGFR\\ALK\\ROS1\\RET\\KRAS\\PIK3CA\\BRAF\\HER2\\MET
  • Patients who met and agreed to surgery or radical chemoradiotherapy, and the remaining samples after cutting tissue sections did not affect the possible further clinical treatment of the subject
  • Provide 20 mL peripheral blood samples periodically
  • The subjects volunteered to join the study, and signed the informed consent form, with good compliance, and actively cooperated with the hospital for routine clinical diagnosis and treatment follow-up

Age in the registry: 18 years to - · Sex: All

Full criteria on ClinicalTrials.gov

Sites (14)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hunan Cancer Hospital
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ChangshaChinaUnknown status
The First Affiliated Hospital of Guangzhou Medical University
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GuangzhouChinaUnknown status
Zhejiang Cancer Hospital
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HangzhouChinaUnknown status
The First Affiliated Hospital of Zhejiang University
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HangzhouChinaUnknown status
Affiliated Cancer Hospital of Harbin Medical University
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HarbinChinaUnknown status
The First Affiliated Hospital of USTC(Anhui Provincial Hospital)
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HefeiChinaUnknown status
Qilu Hospital of Shandong University
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JinanChinaUnknown status
Shandong Provincial Hospital
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JinanChinaUnknown status
Shanghai Chest Hospital
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ShanghaiChinaUnknown status
Zhongshan Hospital Affiliated to Fudan University
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ShanghaiChinaUnknown status
Shanxi Cancer hospital
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TaiyuanChinaUnknown status
First Affiliated Hospital of Xiamen University
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XiamenChinaUnknown status
The First Affiliated Hospital of Xi'an Jiaotong University
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Xi’anChinaUnknown status
The First Affiliated Hospital of Zhengzhou University
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ZhengzhouChinaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.