NCT06444646Recruiting
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.
Source: ClinicalTrials.gov · Last updated 15 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 27 Feb 2023
- Start date
- 20 Feb 2023
- Primary completion date
- Sept 2026
- Lead sponsor
- Hasselt University
- Diseases
- Obesity
- NCT number
- NCT06444646
What you commit to
- Study type: Observational
- Planned participants: 150
- From 20 Feb 2023 to the primary completion date, Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Individuals with obesity - Inclusion Criteria:
- Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery.
- Final male/female ratio of this study is 1:1
- Minimal knowledge of Dutch to read and understand the informed consent.
- Individuals with obesity - Exclusion Criteria:
- Smoking and/or drug abuse
- Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
- Lung and/or kidney diseases
- Brain and/or nerve diseases
- Malignant diseases (e.g. cancer)
- Individuals without obesity (lean) - inclusion criteria
- Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery
- Female only
- Minimal knowledge of Dutch to read and understand the informed consent.
- Individuals without obesity (lean) - exclusion criteria
- Smoking and/or drug abuse
- Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
- Lung and/or kidney diseases
- Brain and/or nerve diseases
- Endocrine diseases like type 2 diabetes
- Malignant diseases (e.g. cancer)
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ziekenhuis Oost-Limburg Coordinator of this site? Confirm its status | Genk | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.