NCT06451198RecruitingPhase 4
IndObufen Versus asPirin After Coronary Drug-eluting Stent implantaTION in Elderly Patients With Acute Coronary Syndrome
Source: ClinicalTrials.gov · Last updated 12 Mar 2026
Brief summary (registry, in English)
The OPTION2 trial (randomized controlled trial of IndObufen versus asPirin after coronary drug-eluting stent implantaTION in elderly patients with acute coronary syndrome) was designed to compare the 1-year clinical efficacy and safety of indobufen-based dual antiplatelet therapy (DAPT) (indobufen 100mg bid plus ticagrelor 90mg bid) or conventional DAPT (aspirin 100mg qd plus ticagrelor 90mg bid) in acute coronary syndrome (ACS) patients aged over 65 years old undergoing coronary drug-eluting stent (DES) implantation.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 2846 (estimated)
- First submitted
- 3 Jun 2024
- Start date
- 19 May 2025
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Shanghai Zhongshan Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06451198
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 2846
- From 19 May 2025 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Elective surgical procedure planned within 12 months
- Concomitant use of oral anticoagulants
Other illness
- Known allergy or intolerance to aspirin, ticagrelor or nonsteroidal anti-inflammatory drugs (NSAIDs)
- History of cerebral hemorrhage
- History of stroke in six months
- Active bleeding
- Active cancer
Other
- Life expectancy ≤1 year
- Known relevant hematological deviations
- Known, clinically important thrombocytopenia (i.e., \<100\*10\^9/L) or anemia (i.e., \<90g/L)
- Active participation in another clinical study
- Other situations in which the investigator considers unsuitable to attend the study
Who the study is looking for
- Age over 65 years old
- Diagnosed with acute coronary syndrome (unstable angina/ non-ST elevation myocardial infarction/ ST elevation myocardial infarction)
- Treated with at least 1 DES implanted in the coronary lesion
- Receiving dual antiplatelet therapy (aspirin plus ticagrelor)
- Agree to attend the trial
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Hospital,Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.