NCT06455293RecruitingPhase 2
Psilocybin Therapy for Depression in Parkinson's Disease
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 30 May 2024
- Start date
- 19 Aug 2024
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Joshua Woolley, MD, PhD
- Diseases
- Parkinson disease
- NCT number
- NCT06455293
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 19 Aug 2024 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Regular use of medications that may have problematic interactions with psilocybin
Other illness
- Significant cognitive impairment
- A health condition that makes this study unsafe or unfeasible, determined by study physicians
Other
- Psychotic symptoms involving loss of insight
Who the study is looking for
- Age 40 to 80
- Comfortable speaking and writing in English
- Have neurologist-diagnosed idiopathic Parkinson's disease (PD), Hoehn and Yahr stages 1 to 3 during an "on" phase (time when medication/DBS for parkinsonian motor feature, including bradykinesia and rigidity is in effect)
- Currently experiencing depressive symptoms
- Able to attend all in-person visits at UCSF as well as virtual visits
- Have a primary care provider, neurologist, or psychiatrist who is actively managing or coordinating
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.