Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

Prior treatment

• Have evidence of prior or current tuberculosis infection as assessed by PPD, interferon gamma release assay or by history
• Require use of other immunosuppressive agents including chronic use of systemic steroids
• Current or ongoing use of non-insulin pharmaceuticals that affect glycemic control within prior 7 days of screening
• Active participation in another T1D treatment study in the previous 30 days
• Prior treatment with any investigational agent to delay beta cell loss in T1D
• Prior treatment with ATG, Verapamil or known allergy to rabbit derived products

Other illness

• Have active signs or symptoms of acute infection at the time of randomization
• Have evidence of current or past HIV, Hepatitis B or Hepatitis C infection
• Have a history of malignancies other than skin
• Known allergy to ATG or Verapamil
• Any condition that in the investigator's opinion may adversely affect study participation or may compromise the study results

Lab values

• Be immunodeficient or have clinically significant chronic lymphopenia: (Leukopenia (\< 3,000 leukocytes /μL), neutropenia (\<1,500 neutrophils/μL), lymphopenia (\<800 lymphocytes/μL), or thrombocytopenia (\<100,000 platelets/μL).
• Have any complicating medical issues or abnormal clinical laboratory results that may interfere with study conduct, or cause increased risk to include pre-existing cardiac disease, COPD, sickle cell disease, neurological, or blood count abnormalities
• Evidence of liver dysfunction with AST or ALT greater than 3 times the upper limits of normal
• Evidence of renal dysfunction with creatinine greater than 1.5 times the upper limit of normal

Other

• Be currently pregnant or lactating, or anticipate getting pregnant within the two year study period
• Vaccination with a live virus within the last 6 weeks

• Must be \>= 6 years \<= 35
• Must have a diagnosis of T1D for less than 100 days at randomization
• Willing to provide Informed Consent or have a parent or legal guardian provide informed consent if the subject is \<18 years of age
• Positive for at least one islet cell autoantibody; GAD65A, mIAA, if obtained within 10 days of the onset of insulin therapy, IA-2A, ICA, or ZnT8A
• Must have stimulated C-peptide levels of 0.2 pmol/ml measured during a mixed meal tolerance test (MMTT) conducted at least 21 days from diagnosis of diabetes. Randomization should occur within one month (37 days) of the MMTT.
• Subjects who are EBV seronegative at screening must be EBV PCR negative within 30 days of randomization and may not have had signs or symptoms of an EBV compatible illness lasting longer than 7 days within 30 days of randomization
• Be at least 6 weeks from last live immunization
• Participants are required to receive killed influenza vaccination at least 2 weeks prior to randomization when vaccine for the current or upcoming flu season is available
• Be willing to forgo live vaccines during the treatment period and for 3 months following last dose of study drug
• Be willing to comply with intensive diabetes management