NCT06457217Recruiting
MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Magnetic Resonance Spectroscopic Imaging Evaluation for Understanding Acute Minor Stroke With Large Vessel Occlusion Evolution Study
Source: ClinicalTrials.gov · Last updated 16 Oct 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 10 Jun 2024
- Start date
- 15 Aug 2024
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Shanghai 6th People's Hospital
- Diseases
- Stroke
- NCT number
- NCT06457217
What you commit to
- Study type: Observational
- Planned participants: 75
- From 15 Aug 2024 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism;
Other illness
- Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases;
- Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders).
Other
- A pre-incident mRS ≥ 1 point before onset;
- Intolerance or non-cooperation with magnetic resonance examination;
- Pregnancy or lactation;
- Life expectancy is less than 3 months;
Who the study is looking for
- Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery;
- Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)\<6);
- Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital;
- Time from symptom onset or last known normal to enrollment is less than 24 hours;
- Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.