NCT06458153Recruiting
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
High-resolution Functional Imaging of Speech-induced Sensory Modulation
Source: ClinicalTrials.gov · Last updated 18 Jun 2026
Brief summary (registry, in English)
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 3 Jun 2024
- Start date
- 27 May 2025
- Primary completion date
- 31 Jul 2028
- Lead sponsor
- University of Pittsburgh
- Diseases
- Stroke
- NCT number
- NCT06458153
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 27 May 2025 to the primary completion date, 31 Jul 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
Other illness
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- History of severe claustrophobia
- History of neurological / neurodegenerative disease or severe brain injury other than stroke
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- History of severe claustrophobia
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- History of severe claustrophobia
Other
- Cohort 1 (neurotypical adults):
- Hearing loss, defined by pure tone thresholds \>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
- Head circumference greater than 60cm or weight greater than 300 pounds
- Currently pregnant
- Cohort 2 (people with cerebellar lesions):
- Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
- Head circumference greater than 60cm or weight greater than 300 pounds
- Currently pregnant
- Cohort 3 (controls matched to Cohort 2):
- Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
- Head circumference greater than 60cm or weight greater than 300 pounds
- Currently pregnant
Who the study is looking for
- Cohort 1 (neurotypical adults):
- Age 18-49
- Right-handed
- Native English speaker
- Cohort 2 (people with cerebellar lesions):
- Age 18 or older
- Right-handed
- Native English speaker
- History of cerebellar stroke
- Cohort 3 (controls matched to Cohort 2)
- Age 18 or older
- Right-handed
- Native English speaker
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.