MK-2870 in Second-line Recurrent or Metastatic Cervical Cancer.

Prior treatment

• Concurrent active Hepatitis B and active Hepatitis C virus infection.
• Participants who have not adequately recovered from major surgery or have ongoing surgical complications.
• Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease (eg, Crohn’s disease, ulcerative colitis, or chronic diarrhea).
• Received prior systemic anticancer therapy.
• Received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids.
• Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed.

Other illness

• Active infection requiring systemic therapy.
• HIV-infected participants with a history of Kaposi’s sarcoma and/or Multicentric Castleman’s Disease.
• Severe hypersensitivity (≥Grade 3) to sacituzumab tirumotecan or treatment of physician’s choice (TPC) and/or any of their excipients, or other biologic therapy.
• Has a history of (noninfectious) pneumonitis/ILD that required steroids or has current pneumonitis/ILD.
• Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing.
• Has uncontrolled, significant cardiovascular disease or cerebrovascular disease.
• Has other histological subtypes of cervical cancer apart from squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma (eg, carcinosarcoma), or has a diagnosis of nonepithelial cancer (eg, sarcoma, neuroendocrine tumors) of the cervix.
• Known additional malignancy that is progressing or has required active treatment within the past 3 years.

Other

• Has Grade ≥2 peripheral neuropathy.
• Known active central nervous system (CNS) metastases and/or carcinomatous meningitis.

• Has histologically-confirmed diagnosis of squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix.
• Has adequate organ function.
• Has recurrent or metastatic cervical cancer.
• Has measurable disease per Response Evaluation Criteria In Solid Tumors (RECIST) 1.1, as assessed by the investigator. Lesions situated in a previously irradiated area are considered measurable if progression has been shown in such lesions.
• Is assigned female sex at birth, at least 18 years of age at the time of providing the informed consent.
• Has ECOG performance status of 0 or 1 within 7 days before allocation for the MK-2870 Run-in or within 7 days before randomization for the Phase 3 portion.
• Has provided tumor tissue (most recent sample is preferred) from a core or excisional biopsy of a tumor lesion not previously irradiated.
• HIV-infected participants must have well controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART).
• Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load prior to allocation (MK-2870 Run-in) or randomization (Phase 3 portion).
• Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.