NCT06464029Recruiting
Pathways Mediating Impaired Postural Control in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 2 Jul 2026
Brief summary (registry, in English)
The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 160 (estimated)
- First submitted
- 10 Jun 2024
- Start date
- 1 Jun 2024
- Primary completion date
- 10 Jun 2027
- Lead sponsor
- University of Minnesota
- Diseases
- Parkinson disease
- NCT number
- NCT06464029
What you commit to
- Study type: Observational
- Planned participants: 160
- From 1 Jun 2024 to the primary completion date, 10 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subjects who are on anti-coagulant medications.
Other illness
- Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers.
- Any musculoskeletal disorder that affects the ability to stand.
- History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury.
- History of surgery on blood vessels, brain or heart.
- Moderate to severe hearing impairment.
- Dementia diagnosis
- Other significant neurological disorders that may affect participation or performance in the study
Other
- Intracranial metallic or magnetic devices.
- Pacemaker or any implanted device.
- Unexplained, recurring headaches or concussion within the last six months.
- Subjects who are pregnant.
- Implanted deep brain stimulator or other neurosurgeries to treat PD.
Who the study is looking for
- Participants with Parkinson's disease
- Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria.
- Age 45-80 years.
- Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
- Healthy Older Adults (Control participants)
- Age 45-80 years (this group will be age and sex-matched to the PD group)
- Able to ambulate independently without the use of an assistive device (cane or walker)
- Healthy Young Adults
- Age 21-44 years (this group will be age and sex-matched to the PD group)
- Able to ambulate independently without the use of an assistive device (cane or walker)
Age in the registry: 45 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.