NCT06464237Recruiting
Metacognitive Intervention in Youth With Oncological Disease - the Mio Study
Source: ClinicalTrials.gov · Last updated 26 Nov 2025
Brief summary (registry, in English)
The aim of the Mio-Study is to address the current lack of effective treatment options to reduce cognitive and physical long-term problems in children and adolescents with cancer. Through the use of the Mio-App, cognitive and physical development will be strengthened and metacognitive thinking and awareness will increase. The Mio-App for children and adolescence with cancer will include a combination of cognitive and physical training tasks and prospective as well as retrospective metacognitive questions. In a randomized controlled trial, the App will be analysed for its efficacy on metacognitive thinking and executive functions. In particular, the investigators are interested in factors that affect the efficacy of the training program such as compliance, age, sex or the presence of fatigue. This study will give insight into the role of metacognition in cognitive and physical performance and will foster the development of children and adolescents with cancer in the long-term.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 12 Jun 2024
- Start date
- 1 Aug 2025
- Primary completion date
- 1 May 2027
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- Diseases
- Childhood cancers
- NCT number
- NCT06464237
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Aug 2025 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Drug or alcohol abuse
Other illness
- Any other instable neurological condition (e.g. epilepsy)
- A severe psychiatric disease (e.g., eating disorder) or severe learning disability
Other
- Known or suspected non-compliance
- Inability to follow the procedures of the study, e.g. due to language problems
- Enrolment of the investigator, his/her family members, employees and other dependent persons
Who the study is looking for
- Informed consent as documented by signature (see Informed Consent Form) of participants and / or parents / legal guardians
- Age 8-16 years
- A diagnosis of cancer either with or without CNS involvement. The participant will be included between 3 months before to 10 years after termination of treatment.
- Treatment of cancer including either radiation, chemotherapy and/ or surgical tumor removal
- German or French speaking
Age in the registry: 8 years to 16 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Insespital, University Hospital Bern Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
Related publications
- A Metacognitive Intervention for Children and Adolescents in Neuropediatric Care (Mio-Training): Protocol for a Randomized Controlled Trial.JMIR Res Protoc · 2026 · PMID 42361358
This page is information, not medical advice. Discuss any trial with your doctor.