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NCT06465186CompletedPhase 2

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Efinopegdutide (MK-6024) in Adults With Compensated Cirrhosis Secondary to Metabolic Dysfunction-Associated Steatohepatitis

Source: ClinicalTrials.gov · Last updated 21 Sept 2026

Brief summary (registry, in English)

Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn: * If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver * About the safety of efinopegdutide and how well people tolerate it

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
85 (actual)
First submitted
13 Jun 2024
Start date
12 Jul 2024
Primary completion date
3 Aug 2026
Lead sponsor
Merck Sharp & Dohme LLC
NCT number
NCT06465186
EU CT number
2024-510923-20-00

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 85
  • From 12 Jul 2024 to the primary completion date, 3 Aug 2026
  • 69 sites in 11 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Had a bariatric surgical procedure less than 5 years before entry into the study

Other illness

  • Has history of a liver disease other than MASH, for example, Hepatitis B or C, drug-induced liver disease, or autoimmune liver disease
  • Has history of type 1 diabetes
  • History of pancreatitis
  • Major illnesses like recent (within 6 months of study entry) episodes of heart problems, such as congestive heart failure, unstable angina, heart attack, stroke, or mini-stroke

Other

  • The main exclusion criteria include but are not limited to the following:

Who the study is looking for

  • The main inclusion criteria include but are not limited to the following:
  • Has compensated cirrhosis caused by metabolic dysfunction-associated steatohepatitis (MASH)
  • Has either type 2 diabetes that is controlled by diet or medication, or does not have type 2 diabetes

Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (69)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Flinders Medical Centre-Hepatology and Liver Transplant Medicine ( Site 1202)
Coordinator of this site? Confirm its status
AdelaideAustraliaUnknown status
St Vincent's Hospital-Gastroenterology Department ( Site 1205)
Coordinator of this site? Confirm its status
MelbourneAustraliaUnknown status
Diex Recherche Quebec ( Site 0204)
Coordinator of this site? Confirm its status
QuébecCanadaUnknown status
Toronto General Hospital ( Site 0207)
Coordinator of this site? Confirm its status
TorontoCanadaUnknown status
Fundacion Santa Fe de Bogota ( Site 0403)
Coordinator of this site? Confirm its status
BogotáColombiaUnknown status
Fundación Valle del Lili ( Site 0402)
Coordinator of this site? Confirm its status
CaliColombiaUnknown status
Complexo Hospitalario Universitario A Coruña
Coordinator of this site? Confirm its status
A CoruñaSpainCompleted
Hospital Universitari Vall d'Hebron
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BarcelonaSpainCompleted
Hospital Universitario La Paz
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MadridSpainCompleted
Hospital General Universitario Gregorio Marañón
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MadridSpainCompleted
Hospital Universitario Marqués de Valdecilla
Coordinator of this site? Confirm its status
SantanderSpainCompleted
Complexo Hospitalario Universitario De Santiago
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Santiago de CompostelaSpainCompleted
University Hospital Virgen Del Rocio S.L.
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SevillaSpainCompleted
Hospital General De Tomelloso
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TomellosoSpainCompleted
Hospital Clínico Universitario de Valladolid
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ValladolidSpainCompleted
Assistance Publique Hopitaux De Paris
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ClichyFranceCompleted
Centre Hospitalier Et Universitaire De Limoges
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Limoges Cedex 1FranceCompleted
Hopital De La Croix-Rousse
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Lyon Cedex 04FranceCompleted
Centre Hospitalier Universitaire de Nice
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NiceFranceCompleted
Centre Hospitalier Universitaire de Bordeaux
Coordinator of this site? Confirm its status
PessacFranceCompleted
Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 1102)
Coordinator of this site? Confirm its status
AberdeenUnited KingdomUnknown status
King's College Hospital ( Site 1104)
Coordinator of this site? Confirm its status
LondonUnited KingdomUnknown status
Carmel Hospital-Liver Unit ( Site 0802)
Coordinator of this site? Confirm its status
HaifaIsraelUnknown status
Rambam Health Care Campus ( Site 0801)
Coordinator of this site? Confirm its status
HaifaIsraelUnknown status
Shaare Zedek Medical Center ( Site 0805)
Coordinator of this site? Confirm its status
JerusalemIsraelUnknown status
Maccabi Health Services - Petah Tikva ( Site 0804)
Coordinator of this site? Confirm its status
Petah TikvaIsraelUnknown status
Assuta Medical Center ( Site 0806)
Coordinator of this site? Confirm its status
Tel AvivIsraelUnknown status
Shinyurigaoka General Hospital ( Site 1401)
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KawasakiJapanUnknown status
University Hospital,Kyoto Prefectural University of Medicine ( Site 1404)
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KyotoJapanUnknown status
Osaka Metropolitan University Hospital ( Site 1403)
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OsakaJapanUnknown status
Saga University Hospital ( Site 1405)
Coordinator of this site? Confirm its status
SagaJapanUnknown status
Yokohama City University Hospital ( Site 1402)
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YokohamaJapanUnknown status
ISIS CLINICAL RESEARCH CENTER ( Site 0606)
Coordinator of this site? Confirm its status
GuaynaboPuerto RicoUnknown status
Klinical Investigations Group-Clinical Research ( Site 0601)
Coordinator of this site? Confirm its status
San JuanPuerto RicoUnknown status
Chulalongkorn University ( Site 1301)
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BangkokThailandUnknown status
Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 1302)
Coordinator of this site? Confirm its status
BangkokThailandUnknown status
Southwest Gastroenterology Associates ( Site 0129)
Coordinator of this site? Confirm its status
AlbuquerqueUnited StatesUnknown status
Texas Clinical Research Institute ( Site 0126)
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ArlingtonUnited StatesUnknown status
Pinnacle Clinical Research ( Site 0104)
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AustinUnited StatesUnknown status
Delta Research Partners ( Site 0160)
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BastropUnited StatesUnknown status
Synergy Healthcare ( Site 0118)
Coordinator of this site? Confirm its status
BradentonUnited StatesUnknown status
The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149)
Coordinator of this site? Confirm its status
ChandlerUnited StatesUnknown status
University of Virginia Health System ( Site 0164)
Coordinator of this site? Confirm its status
CharlottesvilleUnited StatesUnknown status
Pinnacle Clinical Research-Corpus Christi ( Site 0156)
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Corpus ChristiUnited StatesUnknown status
Zenos Clinical Research ( Site 0136)
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DallasUnited StatesUnknown status
Southeast Clinical Research Center ( Site 0119)
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DaltonUnited StatesUnknown status
Coastal Research Institute - Fayetteville ( Site 0159)
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FayettevilleUnited StatesUnknown status
Arizona Clinical Trials ( Site 0158)
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FlagstaffUnited StatesUnknown status
GI Alliance Department of Research ( Site 0162)
Coordinator of this site? Confirm its status
Fort WorthUnited StatesUnknown status
Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130)
Coordinator of this site? Confirm its status
Glen BurnieUnited StatesUnknown status
Homestead Associates in Research, Inc. ( Site 0139)
Coordinator of this site? Confirm its status
HomesteadUnited StatesUnknown status
Houston Research Institute ( Site 0117)
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HoustonUnited StatesUnknown status
Houston Research Institute ( Site 0172)
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HoustonUnited StatesUnknown status
Florida Research Institute ( Site 0116)
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Lakewood RchUnited StatesUnknown status
Excel Clinical Research, LLC ( Site 0101)
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Las VegasUnited StatesUnknown status
The Machuca Foundation ( Site 0115)
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Las VegasUnited StatesUnknown status
Rocky Mountain Gastroenterology ( Site 0127)
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LittletonUnited StatesUnknown status
Floridian Clinical Research, LLC ( Site 0109)
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Miami LakesUnited StatesUnknown status
Lucas Research, Inc ( Site 0105)
Coordinator of this site? Confirm its status
Morehead CityUnited StatesUnknown status
California Liver Research Institute ( Site 0113)
Coordinator of this site? Confirm its status
PasadenaUnited StatesUnknown status
The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120)
Coordinator of this site? Confirm its status
PeoriaUnited StatesUnknown status
Velocity Clinical Research Rockville ( Site 0143)
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RockvilleUnited StatesUnknown status
American Research Corporation ( Site 0131)
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San AntonioUnited StatesUnknown status
Pinnacle Clinical Research-Clinical Research Coordination ( Site 0125)
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San AntonioUnited StatesUnknown status
Acclaim Clinical Research ( Site 0137)
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San DiegoUnited StatesUnknown status
Louisiana Research Center ( Site 0161)
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ShreveportUnited StatesUnknown status
The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111)
Coordinator of this site? Confirm its status
TucsonUnited StatesUnknown status
Velocity Clinical Research, Panorama City ( Site 0124)
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Van NuysUnited StatesUnknown status
Huron Gastroenterology ( Site 0102)
Coordinator of this site? Confirm its status
YpsilantiUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.