NCT06465186CompletedPhase 2
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Efinopegdutide (MK-6024) in Adults With Compensated Cirrhosis Secondary to Metabolic Dysfunction-Associated Steatohepatitis
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn: * If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver * About the safety of efinopegdutide and how well people tolerate it
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 85 (actual)
- First submitted
- 13 Jun 2024
- Start date
- 12 Jul 2024
- Primary completion date
- 3 Aug 2026
- Lead sponsor
- Merck Sharp & Dohme LLC
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT06465186
- EU CT number
- 2024-510923-20-00
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 85
- From 12 Jul 2024 to the primary completion date, 3 Aug 2026
- 69 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Had a bariatric surgical procedure less than 5 years before entry into the study
Other illness
- Has history of a liver disease other than MASH, for example, Hepatitis B or C, drug-induced liver disease, or autoimmune liver disease
- Has history of type 1 diabetes
- History of pancreatitis
- Major illnesses like recent (within 6 months of study entry) episodes of heart problems, such as congestive heart failure, unstable angina, heart attack, stroke, or mini-stroke
Other
- The main exclusion criteria include but are not limited to the following:
Who the study is looking for
- The main inclusion criteria include but are not limited to the following:
- Has compensated cirrhosis caused by metabolic dysfunction-associated steatohepatitis (MASH)
- Has either type 2 diabetes that is controlled by diet or medication, or does not have type 2 diabetes
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (69)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Flinders Medical Centre-Hepatology and Liver Transplant Medicine ( Site 1202) Coordinator of this site? Confirm its status | Adelaide | Australia | Unknown status |
| St Vincent's Hospital-Gastroenterology Department ( Site 1205) Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Diex Recherche Quebec ( Site 0204) Coordinator of this site? Confirm its status | Québec | Canada | Unknown status |
| Toronto General Hospital ( Site 0207) Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Fundacion Santa Fe de Bogota ( Site 0403) Coordinator of this site? Confirm its status | Bogotá | Colombia | Unknown status |
| Fundación Valle del Lili ( Site 0402) Coordinator of this site? Confirm its status | Cali | Colombia | Unknown status |
| Complexo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Completed |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital General Universitario Gregorio Marañón Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Marqués de Valdecilla Coordinator of this site? Confirm its status | Santander | Spain | Completed |
| Complexo Hospitalario Universitario De Santiago Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Completed |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Hospital General De Tomelloso Coordinator of this site? Confirm its status | Tomelloso | Spain | Completed |
| Hospital Clínico Universitario de Valladolid Coordinator of this site? Confirm its status | Valladolid | Spain | Completed |
| Assistance Publique Hopitaux De Paris Coordinator of this site? Confirm its status | Clichy | France | Completed |
| Centre Hospitalier Et Universitaire De Limoges Coordinator of this site? Confirm its status | Limoges Cedex 1 | France | Completed |
| Hopital De La Croix-Rousse Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Completed |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Completed |
| Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Completed |
| Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 1102) Coordinator of this site? Confirm its status | Aberdeen | United Kingdom | Unknown status |
| King's College Hospital ( Site 1104) Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Carmel Hospital-Liver Unit ( Site 0802) Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Rambam Health Care Campus ( Site 0801) Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Shaare Zedek Medical Center ( Site 0805) Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Maccabi Health Services - Petah Tikva ( Site 0804) Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Assuta Medical Center ( Site 0806) Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Shinyurigaoka General Hospital ( Site 1401) Coordinator of this site? Confirm its status | Kawasaki | Japan | Unknown status |
| University Hospital,Kyoto Prefectural University of Medicine ( Site 1404) Coordinator of this site? Confirm its status | Kyoto | Japan | Unknown status |
| Osaka Metropolitan University Hospital ( Site 1403) Coordinator of this site? Confirm its status | Osaka | Japan | Unknown status |
| Saga University Hospital ( Site 1405) Coordinator of this site? Confirm its status | Saga | Japan | Unknown status |
| Yokohama City University Hospital ( Site 1402) Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
| ISIS CLINICAL RESEARCH CENTER ( Site 0606) Coordinator of this site? Confirm its status | Guaynabo | Puerto Rico | Unknown status |
| Klinical Investigations Group-Clinical Research ( Site 0601) Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Unknown status |
| Chulalongkorn University ( Site 1301) Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 1302) Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Southwest Gastroenterology Associates ( Site 0129) Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Texas Clinical Research Institute ( Site 0126) Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Pinnacle Clinical Research ( Site 0104) Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Delta Research Partners ( Site 0160) Coordinator of this site? Confirm its status | Bastrop | United States | Unknown status |
| Synergy Healthcare ( Site 0118) Coordinator of this site? Confirm its status | Bradenton | United States | Unknown status |
| The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149) Coordinator of this site? Confirm its status | Chandler | United States | Unknown status |
| University of Virginia Health System ( Site 0164) Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| Pinnacle Clinical Research-Corpus Christi ( Site 0156) Coordinator of this site? Confirm its status | Corpus Christi | United States | Unknown status |
| Zenos Clinical Research ( Site 0136) Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Southeast Clinical Research Center ( Site 0119) Coordinator of this site? Confirm its status | Dalton | United States | Unknown status |
| Coastal Research Institute - Fayetteville ( Site 0159) Coordinator of this site? Confirm its status | Fayetteville | United States | Unknown status |
| Arizona Clinical Trials ( Site 0158) Coordinator of this site? Confirm its status | Flagstaff | United States | Unknown status |
| GI Alliance Department of Research ( Site 0162) Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130) Coordinator of this site? Confirm its status | Glen Burnie | United States | Unknown status |
| Homestead Associates in Research, Inc. ( Site 0139) Coordinator of this site? Confirm its status | Homestead | United States | Unknown status |
| Houston Research Institute ( Site 0117) Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Houston Research Institute ( Site 0172) Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Florida Research Institute ( Site 0116) Coordinator of this site? Confirm its status | Lakewood Rch | United States | Unknown status |
| Excel Clinical Research, LLC ( Site 0101) Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| The Machuca Foundation ( Site 0115) Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Rocky Mountain Gastroenterology ( Site 0127) Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Floridian Clinical Research, LLC ( Site 0109) Coordinator of this site? Confirm its status | Miami Lakes | United States | Unknown status |
| Lucas Research, Inc ( Site 0105) Coordinator of this site? Confirm its status | Morehead City | United States | Unknown status |
| California Liver Research Institute ( Site 0113) Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120) Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Velocity Clinical Research Rockville ( Site 0143) Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
| American Research Corporation ( Site 0131) Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Pinnacle Clinical Research-Clinical Research Coordination ( Site 0125) Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Acclaim Clinical Research ( Site 0137) Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Louisiana Research Center ( Site 0161) Coordinator of this site? Confirm its status | Shreveport | United States | Unknown status |
| The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111) Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Velocity Clinical Research, Panorama City ( Site 0124) Coordinator of this site? Confirm its status | Van Nuys | United States | Unknown status |
| Huron Gastroenterology ( Site 0102) Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.