NCT06465498Recruiting
Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography
Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography (IcarUS) : a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 1 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes. The main questions it aims to answer are: * Does this strategy shorten the length of stay and reduce early hospital readmissions? * Does this strategy improve patients' symptoms and quality of life ? Researchers will compare LUS to physical examination (PE).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 222 (estimated)
- First submitted
- 13 Jun 2024
- Start date
- 22 Oct 2024
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Antonio Leidi
- Diseases
- Heart failure
- NCT number
- NCT06465498
What you commit to
- Study type: Interventional
- Planned participants: 222
- From 22 Oct 2024 to the primary completion date, 30 Apr 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known isolated right heart failure
- The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion
Other
- Systolic blood pressure \<90 mmHg, mean arterial pressure \<65 mmHg at the moment of inclusion
- Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months
- Unwillingness to give consent
- Subjects who are pregnant or breastfeeding
- Hospitalisation for palliative care and probable end-life within 30 days
Who the study is looking for
- ≥ 18 years old
- Planned or actual admission to intermediate care units, general internal medical or cardiology wards
- Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis)
- Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng/l).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Inselspital, Universitätspital Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Fribourg University Hospital Coordinator of this site? Confirm its status | Fribourg | Switzerland | Recruiting |
| Trois-Chêne Hospital, Geneva Univesity Hospitals Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Geneva University Hospitals Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Ospedale Civico, Ente Ospedaliero Cantonale Coordinator of this site? Confirm its status | Lugano | Switzerland | Terminated |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.