NCT06467695Recruiting
Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls
Source: ClinicalTrials.gov · Last updated 6 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantly improve the self-reported level of depression and apathy in patients with PD from pre-intervention to post-intervention compared to a sham control? 2) Can the use of mgTDCS significantly normalize the cortical eeg alpha asymmetry so commonly seen in depressed patients compared to sham mgTDCS? 3) Can the use of mgTDCS significantly improve scores on neuropsychological tests of working memory?
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 1 May 2024
- Start date
- 1 Aug 2024
- Primary completion date
- 1 May 2027
- Lead sponsor
- University of South Alabama
- Diseases
- Parkinson disease
- NCT number
- NCT06467695
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Aug 2024 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- No history of or being treated for epilepsy or other seizure disorders.
- No history of penetrating head wounds or TBI greater than mild TBI.
- No history of atypical Parkinson's
Who the study is looking for
- 19 to 65 years in age.
- Parkinson's Group must have a physician dx of Parkinson's Disease
- Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above).
- Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions.
- Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician.
- Read and understand spoken English.
Age in the registry: 19 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of South Alabama Coordinator of this site? Confirm its status | Mobile | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.