NCT06471569Completed
Role of Aging and Individual Variation in Exercise Training Responsiveness
The Role of Aging and Individual Variation in Exercise Training Responsiveness
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 26 participants to complete a 6-month aerobic exercise intervention.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 9 (actual)
- First submitted
- 10 Jun 2024
- Start date
- 2 Apr 2025
- Primary completion date
- 29 May 2026
- Lead sponsor
- Duke University
- Diseases
- Obesity
- NCT number
- NCT06471569
What you commit to
- Study type: Interventional
- Participants enrolled: 9
- From 2 Apr 2025 to the primary completion date, 29 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Insulin-dependent diabetes
- Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
- Current, actively treated malignancy other than dermatologic conditions
- Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
- Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
- Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
Other
- Poor vein access
- Current use of tobacco or any nicotine products, including e-cigarettes
- Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations \> 10.0 uIU/mL
- Unable to safely participate in an exercise program per study protocol per PI discretion
- Planned, intentional weight loss during study
Who the study is looking for
- Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
- Body Mass Index (BMI) \> 18 and \< 45 kg/m2
- Stable dose (≥1 month) of any cardiometabolic medications
Age in the registry: 60 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke Center for Living Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.