NCT06472336Recruiting
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting - a Pragmatic, International, Multicentre, Randomized Trial
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 498 (estimated)
- First submitted
- 10 Jun 2024
- Start date
- 31 Mar 2025
- Primary completion date
- Aug 2027
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Stroke
- NCT number
- NCT06472336
What you commit to
- Study type: Interventional
- Planned participants: 498
- From 31 Mar 2025 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Evidence of an ongoing pregnancy prior to randomization
- Evidence of vessel recanalization prior to randomisation
Other illness
- Acute intracranial haemorrhage
- Pre-stroke modified Rankin Scale score of 3 or above
- Known, severe comorbidities, which will likely prevent improvement or follow-up (cancer, alcohol/drug abuse or dementia)
- Known clotting disease or suspicion of underlying disease which might lead to a hyper coagulant state
- In-hospital Stroke
Lab values
- Known contraindications for anti-platelet therapy
Other
- Known (serious) sensitivity to radiographic contrast agents, nickel, titanium metals or their alloys
- Foreseeable difficulties in follow-up due to geographic reasons (e.g., patients living abroad)
- Radiological confirmed evidence of mass effect or intracranial tumour (except small meningioma)
- Radiological confirmed evidence of cerebral vasculitis
- Participation in another interventional trial which could confound the primary endpoint
Who the study is looking for
- A relevant clinical deficit defined as a National Institute of Health Stoke Scale (NIHSS) Score of ≥ 6 points for anterior circulation stroke and a NIHSS Score of ≥ 10 for posterior circulation stroke
- Anticipated randomization within 24 hours of last seen well (LSW)
- Occlusion of the Internal Carotid Artery, the M1 segment, the proximal/dominant M2 segment of the Middle Cerebral Artery, the Basilar Artery or the V4 segment of the Vertebral Artery
- Absence of recanalization (thrombolysis in myocardial infarction score of 0 or 1) after up to three endovascular treatment passes
- High probability of underlying intracranial atherosclerotic disease based on the assessment of the treating physician
- Age ≥ 18 years
- Occluded artery amendable to stenting by judgement of the treating physician
- Absence of a large infarct core defined as (posterior circulation) Alberta Stroke Program Early CT Score of 6 or above
- Informed Consent as documented by signature or fulfilling the criteria for emergency consent procedures
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Basel, Department of Interventional and Diagnostical Neuroradiology Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.