NCT06476847Completed
A Simple Intervention to Increase Persistence on PrEP in MSM to Improve Decision Making
The Role of Cognitive Biases in the Decision to Request, Offer, Accept and Continue on PrEP From a Health Care Provider and Patient Perspective (Men Who Have Sex With Men)
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality that requires individuals to take a daily tablet to prevent themselves acquiring HIV. In South Africa while this is freely available in the public sector, persistence (that is continuation after initiation) is low amongst vulnerable populations, including men who have sex with men (MSM). This study is a feasibility and acceptability study of a behavioral economics informed intervention to improve persistence amongst MSM newly initiating PrEP in South Africa. The goal of this study is to show that this approach is possible in a routine setting and gather the necessary data for a fully powered effectiveness trial. Study participants will complete a baseline questionnaire and then be randomized to either receive standard of care (control) or to receive the intervention. The intervention package consists of evidence informed reminders, commitment pledges and planning prompts. The intervention package aims to address present bias, optimism bias and salience. The intervention is delivered and the enrollment visit and then through mobile phone reminders / text messages. There is no further in person interaction after the initial interaction. Participants may be contacted for a telephonic enplane questionnaire. Outcome data is obtained from passive followup through routine medical record review with the primary end point being persistence at 3 months.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 106 (actual)
- First submitted
- 21 Jun 2024
- Start date
- 23 Jan 2025
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- Boston University
- Diseases
- HIV
- NCT number
- NCT06476847
What you commit to
- Study type: Interventional
- Participants enrolled: 106
- From 23 Jan 2025 to the primary completion date, 28 Feb 2026
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous PrEP experience within the last year (12 months from enrolment)
Other
- PrEP status unknown
Who the study is looking for
- Not currently on pre exposure prophylaxis (PrEP); no PrEP within the last 12 months
- Initiating PrEP on the date of enrolment
- Access to a mobile phone
- Willing and able to provide written informed consent in English
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boston Univeristy School ofPublic Health, Global Health Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| The Aurum POP INN Clinic Coordinator of this site? Confirm its status | Pretoria | South Africa | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.