NCT06483438Completed
Handwriting as an Objective Tool to Support the Identification of People With Alzheimer's Disease
Handwriting as an Objective Tool to Support the Identification of People With Alzheimer's Disease: Suitability of an Assessment Protocol
Source: ClinicalTrials.gov · Last updated 9 Aug 2024
Brief summary (registry, in English)
Alzheimer's disease (AD) is the most common of dementia, and has associated cognitive and motor disorders, with consequences on daily activities, including handwriting. Handwriting has been used to study fine motor control or executive functioning in healthy and unhealthy populations. Changes in this skill are present at different stages of the clinical course of Alzheimer's Disease. The sensorimotor deterioration is observed in handwriting tasks (motion kinematics, such as movement time, speed, and profiles) and brain activity rhythms. Handwriting has been used to study fine motor control or executive functioning in healthy and unhealthy populations, and changes in this skill are present at different stages of the clinical course of dementia. From a theoretical perspective, because sensorimotor deterioration observed in handwriting tasks (motion kinematics, such as movement time, speed, and profiles). Due to the large number of brain areas related to handwriting performance, brain electrical activity analysis can be an early indicator of brain dysfunction. Although there is a lack of validation across healthy and non-healthy populations Electroencephalogram (EEG) measures have the potential for evaluating cognitive performance. This research aims to analyze the suitability of the handwriting assessment protocol, which can contribute to a more in-depth knowledge of this subject and potentially support early identification and treatment.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 20 (actual)
- First submitted
- 7 Jun 2024
- Start date
- 2 Dec 2023
- Primary completion date
- 30 Jul 2024
- Lead sponsor
- University of Évora
- Diseases
- Alzheimer disease
- NCT number
- NCT06483438
What you commit to
- Study type: Observational
- Participants enrolled: 20
- From 2 Dec 2023 to the primary completion date, 30 Jul 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \- Previous neurological history (e.g. stroke, traumatic brain injury, multiple sclerosis, among others), psychiatric history or other incapacitating illnesses that could interfere with the collection of writing data. (NOTE that neurological disease is accepted in the dementia group, but co-morbidity of previous and actual neurological diseases will be excluded) Cognitively normal group
Other illness
- \- Presence of neurological history (e.g., stroke, traumatic brain injury, multiple sclerosis, among others), psychiatric history, or other incapacitating illnesses that could interfere with the collection of writing data.
Who the study is looking for
- Over 50 years of age
- The inclusion criteria for the dementia group are as follows: patients diagnosed with dementia according to the DSM-5 criteria and cognitive impairment proven in the neuropsychological assessment
- Portuguese native language
- Over 50 years of age
- At least three years of schooling
Criteria the registry did not label
- Dementia group
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Espírito Santo Hospital of Évora Coordinator of this site? Confirm its status | Evora | Portugal | Unknown status |
| Casa dos Avós Residence Coordinator of this site? Confirm its status | Ponte de Sôr | Portugal | Unknown status |
| Costa Azul Residence Coordinator of this site? Confirm its status | Sesimbra | Portugal | Unknown status |
Related publications
- Handwriting speed and pen motor control in older adults with and without cognitive impairment.Front Hum Neurosci · 2026 · PMID 42245916
This page is information, not medical advice. Discuss any trial with your doctor.