NCT06484543Active, not recruiting
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
Source: ClinicalTrials.gov · Last updated 9 Apr 2026
Brief summary (registry, in English)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome. Chronic exposure to MA as a potent PPARgamma binder nutraceutical over 12 weeks will result in improvement in the features of metabolic syndrome including waist circumference, blood pressure, serum HDL-C level, fasting serum triglycerides and fasting plasma glucose. Expected secondary endpoints include favorable changes in metabolic rate, respiratory quotient, fat oxidation, body composition, weight, BAT/WAT compartments, batokines/adipokines, proinflammatory biomarkers, insulin sensitivity and beta cell function.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 4 Jun 2024
- Start date
- 15 Aug 2024
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- Institute for Human Development and Potential (IHDP), Singapore
- Diseases
- Obesity
- NCT number
- NCT06484543
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 15 Aug 2024 to the primary completion date, 31 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have major medical or surgical event requiring hospitalization within the preceding 3 months
- Have taken antibiotics for 3 months before the study period
- Having active Tuberculosis (TB) or currently receiving treatment for TB
- Have any known Chronic Infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Enrolled in a concurrent research study judged not to be scientifically or medically compatible with this study
Other illness
- Have major chronic disease such as heart disease or cancer
- Have any known food allergy (eg. anaphylaxis to peanuts) or skin allergy (eg. rashes due to alcohol, etc)
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
- History of claustrophobia
Lab values
- Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Take insulin or drugs known to affect glucose metabolism
Other
- Are pregnant or contemplating pregnancy (for female subjects)
- Partake in sports at the competitive and/ or endurance levels
- Intentionally restrict food intake
- Are a smoker
- Are an overnight shift worker
- Are a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted
- Have poor veins impeding venous access
Who the study is looking for
- Male or Female
- Chinese ethnicity
- Age between 21 to 60 years• Able to give informed consent
- Body mass index (BMI) between 23 to 32 kg/m2
- Thyroid function test must be within the normal ranges
- Willing to avail yourself for the whole study and follow study procedures
- EITHER deemed to have pre-metabolic syndrome when waist circumference is \> 90 cm in men or \> 80 cm in women, with none or up to one of the following condition:
- Triglyceride level \>/= 1.7 mmol/L
- HDL cholesterol \</= 1.0 mmol/L in men, and \</= 1.3 mmol/L in women
- Blood pressure \>/= 130/85 mmHg
- Fasting blood glucose \>/= 6.1 mmol/L
- OR deemed to have metabolic syndrome when three or more of the following conditions are present:
- Waist circumference \> 90 cm in men and \> 80 cm in women
- Triglyceride level \>/= 1.7 mmol/L
- HDL cholesterol\</= 1.0 mmol/L in men, and \</= 1.3 mmol/L in women
- Blood pressure \>/= 130/85 mmHg
- Fasting blood glucose \>/= 6.1 mmol/L
Age in the registry: 21 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Singapore Institute of Clinical Sciences Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.