NCT06488482RecruitingPhase 3
Assessment of short immunotherapy after radical surgery of high-risk malignant melanoma
A prospective randomized international multicenter study to compare Short versus Long Adjuvant immunotherapy after radical surgery of stage IIb-c, III and IV cutaneous malignant Melanoma (Grand SLAM)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 19 Oct 2026
Brief summary (registry, in English)
To assess whether adjuvant treatment with immunotherapy for 6 months is as effective as 12 months in patients with stage IIb-c, III and IV cutaneous malignant melanoma.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 1800 (estimated)
- First submitted
- 20 Jun 2024
- Start date
- 15 Nov 2024
- Lead sponsor
- Uppsala University Hospital
- Diseases
- Melanoma
- NCT number
- NCT06488482
- EU CT number
- 2023-509994-22-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 1800
- 30 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- The patient is assessed as unfit to receive systemic adjuvant treatment. 2) An active, known, or suspected autoimmune disease.
Who the study is looking for
- Performance status WHO 0-1. 2) Radical surgery for cutaneous malignant melanoma stage IIb-c, III and IV.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (30)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| HUS-Yhtymae Coordinator of this site? Confirm its status | Helsinki | Finland | Recruiting |
| Kuopio University Hospital Coordinator of this site? Confirm its status | Kuopio | Finland | Recruiting |
| Tampere University Hospital Coordinator of this site? Confirm its status | Tampere | Finland | Recruiting |
| Turku University Hospital Coordinator of this site? Confirm its status | Turku | Finland | Recruiting |
| Helse Moere Og Romsdal HF Coordinator of this site? Confirm its status | Aalesund | Norway | Recruiting |
| Helse Bergen HF Coordinator of this site? Confirm its status | Bergen | Norway | Recruiting |
| Vestre Viken HF Coordinator of this site? Confirm its status | Drammen | Norway | Recruiting |
| Sorlandet Sykehus HF Coordinator of this site? Confirm its status | Kristiansand S | Norway | Recruiting |
| Akershus University Hospital Coordinator of this site? Confirm its status | Lorenskog | Norway | Recruiting |
| Oslo University Hospital HF Coordinator of this site? Confirm its status | Oslo | Norway | Recruiting |
| Helse Stavanger HF Coordinator of this site? Confirm its status | Stavanger | Norway | Recruiting |
| Sykehuset I Vestfold HF Coordinator of this site? Confirm its status | Toensberg | Norway | Recruiting |
| Universitetssykehuset Nord-Norge HF Coordinator of this site? Confirm its status | Tromsoe | Norway | Recruiting |
| St. Olavs hospital HF Coordinator of this site? Confirm its status | Trondheim | Norway | Recruiting |
| Malarsjukhuset Eskilstuna Coordinator of this site? Confirm its status | Eskilstuna | Sweden | Recruiting |
| Region Dalarna Coordinator of this site? Confirm its status | Falun | Sweden | Recruiting |
| Region Gaevleborg Coordinator of this site? Confirm its status | Gavle | Sweden | Recruiting |
| Sahlgrenska University Hospital-Vastra Gotalandsregionen Coordinator of this site? Confirm its status | Goteborg | Sweden | Recruiting |
| Region Joenkoepings Laen Coordinator of this site? Confirm its status | Jonkoping | Sweden | Recruiting |
| Laenssjukhuset I Kalmar Region Kalmar Laen Coordinator of this site? Confirm its status | Kalmar | Sweden | Recruiting |
| Region Vaermland Coordinator of this site? Confirm its status | Karlstad | Sweden | Recruiting |
| Linkoping University Hospital Region Ostergotland Coordinator of this site? Confirm its status | Linkoping | Sweden | Recruiting |
| Region Skane Skanes Universitetssjukhus Coordinator of this site? Confirm its status | Lund | Sweden | Recruiting |
| Region Oerebro Laen Coordinator of this site? Confirm its status | Orebro | Sweden | Recruiting |
| Karolinska University Hospital Coordinator of this site? Confirm its status | Stockholm | Sweden | Recruiting |
| Region Vaesternorrland Coordinator of this site? Confirm its status | Sundsvall | Sweden | Recruiting |
| Region Vaesterbotten Coordinator of this site? Confirm its status | Umea | Sweden | Recruiting |
| Uppsala University Hospital Coordinator of this site? Confirm its status | Uppsala | Sweden | Recruiting |
| Region Vaestmanland Coordinator of this site? Confirm its status | Vasteras | Sweden | Recruiting |
| Region Kronoberg Coordinator of this site? Confirm its status | Vaxjo | Sweden | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.