NCT06492538Recruiting
Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study
Source: ClinicalTrials.gov · Last updated 12 Dec 2025
Brief summary (registry, in English)
The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 1 Jul 2024
- Start date
- 1 Dec 2023
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
- Diseases
- Glaucoma
- NCT number
- NCT06492538
What you commit to
- Study type: Observational
- Planned participants: 300
- From 1 Dec 2023 to the primary completion date, 30 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment;
- Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination;
- Patients with severe systemic diseases;
Other
- Long-term local or systemic use of glucocorticoids;
- Pregnant or lactating women;
- Unable to complete 12-month postoperative follow-up.
Who the study is looking for
- Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation;
- Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry);
- Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol.
Age in the registry: 30 years to 85 years · Sex: All
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Ophthalmic Center Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.