NCT06510816Active, not recruitingPhase 3
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)
A Phase 3, Multicenter, Randomized, Parallel-Group, Double-Masked, 2-Arm, Sham Controlled Study of the Efficacy, Safety, and Tolerability of ANX007 (Vonaprument) Administered by Intravitreal Injection in Participants With Dry Age-Related Macular Degeneration With Geographic Atrophy
Source: ClinicalTrials.gov · Last updated 6 Oct 2026
Brief summary (registry, in English)
The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with dry AMD with GA.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 659 (actual)
- First submitted
- 15 Jul 2024
- Start date
- 30 Jul 2024
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- Annexon, Inc.
- Diseases
- Macular degeneration
- NCT number
- NCT06510816
- EU CT number
- 2024-515022-88-00
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 659
- From 30 Jul 2024 to the primary completion date, 31 Jul 2027
- 138 sites in 14 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Geographic atrophy due to other causes than AMD such as Stargardt disease, cone-rod dystrophy, pathologic myopia, or toxic maculopathies (for example, plaquenil maculopathy) in either eye.
- NOTE: Other protocol-defined inclusion and exclusion criteria apply.
Who the study is looking for
- Diagnosis of dry AMD with GA as determined by the Investigator and confirmed by the independent Central Reading Center.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (138)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Landeskrankenanstalten-Betriebsgesellschaft Kabeg Coordinator of this site? Confirm its status | Klagenfurt Am Woerthersee | Austria | Active, not recruiting |
| Johannes Kepler University Linz Coordinator of this site? Confirm its status | Linz | Austria | Active, not recruiting |
| Eye Clinic Albury Wodonga Coordinator of this site? Confirm its status | Albury | Australia | Unknown status |
| Marsden Eye Specialists Coordinator of this site? Confirm its status | Parramatta | Australia | Unknown status |
| Strathfield Retina Clinic Coordinator of this site? Confirm its status | Strathfield | Australia | Unknown status |
| Sydney Retina Clinic and Day Surgery Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Sydney Eye Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Calgary Retina Consultants Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| Alberta Retina Consultants Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| Ivey Eye Institute Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Retina Centre of Ottawa Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Vseobecna fakultni nemocnice v Praze Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Axon Clinical s.r.o. Coordinator of this site? Confirm its status | Prague 5 | Czechia | Active, not recruiting |
| Universitaetsklinikum Bonn AöR Coordinator of this site? Confirm its status | Bonn | Germany | Active, not recruiting |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Active, not recruiting |
| Augenzentrum Am St Franziskus-Hospital Muenster Coordinator of this site? Confirm its status | Munster | Germany | Active, not recruiting |
| Diakonie Klinikum Dietrich Bonhoeffer GmbH Coordinator of this site? Confirm its status | Neubrandenburg | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Active, not recruiting |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Institut Catala De Retina S.L. Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Oftalmologia Vistahermosa S.L. Coordinator of this site? Confirm its status | Burjassot | Spain | Active, not recruiting |
| Metavision Arruzafa S.L. Coordinator of this site? Confirm its status | Cordoba | Spain | Active, not recruiting |
| Bellvitge University Hospital Coordinator of this site? Confirm its status | L'hospitalet De Llobregat | Spain | Active, not recruiting |
| Clinica Baviera S.A. Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Active, not recruiting |
| Valles Ophthalmology Research S.L. Coordinator of this site? Confirm its status | Sant Cugat Del Valles | Spain | Active, not recruiting |
| Complexo Hospitalario Universitario De Santiago Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Active, not recruiting |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| Hospital Clinico Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Active, not recruiting |
| Hospital Universitario Miguel Servet Coordinator of this site? Confirm its status | Zaragoza | Spain | Active, not recruiting |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Active, not recruiting |
| Centre Hospitalier Intercommunal Créteil Coordinator of this site? Confirm its status | Créteil | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Dijon Coordinator of this site? Confirm its status | Dijon | France | Active, not recruiting |
| Pole Vision Val d'Ouest Coordinator of this site? Confirm its status | Écully | France | Active, not recruiting |
| Hospices Civils De Lyon Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Active, not recruiting |
| Centre Monticelli Paradis d'Ophtalmologie Coordinator of this site? Confirm its status | Marseille | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Active, not recruiting |
| Quinze-Vingts National Ophthalmology Hospital Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Assistance Publique Hopitaux De Paris Coordinator of this site? Confirm its status | Paris Cedex 10 | France | Active, not recruiting |
| Ophtalmologie Maison Rouge S.C.M. Coordinator of this site? Confirm its status | Strasbourg | France | Active, not recruiting |
| Moorfields Eye Hospital NHS foundation Trust Coordinator of this site? Confirm its status | Greater London | United Kingdom | Unknown status |
| King's College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| The Retina Clinic London Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Active, not recruiting |
| Central Hospital Of Northern Pest Military Hospital Coordinator of this site? Confirm its status | Budapest VI | Hungary | Active, not recruiting |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Active, not recruiting |
| Budapest Retina Associates Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Active, not recruiting |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Active, not recruiting |
| Nozologen Kft. Coordinator of this site? Confirm its status | Pécs | Hungary | Active, not recruiting |
| Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Active, not recruiting |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| ASST Fatebenefratelli Sacco Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Multimedica S.p.A. Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Fondazione G.B.Bietti Per Lo Studio E La Ricerca In Oftalmologia Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Stichting Elisabeth-TweeSteden Ziekenhuis Coordinator of this site? Confirm its status | Tilburg | Netherlands | Active, not recruiting |
| Southern Eye Specialists Coordinator of this site? Confirm its status | Christchurch | New Zealand | Unknown status |
| Capital Eye Specialists Coordinator of this site? Confirm its status | Te Aro | New Zealand | Unknown status |
| OFTALMIKA Sp. z o.o Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| Uniwersyteckie Centrum Kliniczne im. Prof K. Gibinskiego Slaskiego Uniwersytetu Medycznego w Katowicach Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o. Coordinator of this site? Confirm its status | Olsztyn | Poland | Active, not recruiting |
| Ośrodek Chirurgii Oka Prof. Zagórskiego Sp. Z o.o. Coordinator of this site? Confirm its status | Rzeszów | Poland | Active, not recruiting |
| Caminomed Sp. z o.o. Coordinator of this site? Confirm its status | Tarnowskie Góry | Poland | Active, not recruiting |
| Warszawski Szpital Okulistyczny Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Retina Research Institute of Texas Coordinator of this site? Confirm its status | Abilene | United States | Unknown status |
| Retina Consultants of Hawaii Coordinator of this site? Confirm its status | ‘Aiea | United States | Unknown status |
| Palmetto Retina Center Coordinator of this site? Confirm its status | Aiken | United States | Unknown status |
| Vision Research Center Eye Associates of New Mexico Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Southwest Retina Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Unknown status |
| Texas Retina Associates - Arlington Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Asheville Eye Associates - Retina Division Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| Austin Research Center for Retina Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Austin Retina Associates Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Austin Clinical Research, LLC Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Retina Consultants of Charleston Coordinator of this site? Confirm its status | Beaufort | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Retina-Vitreous Associates Medical Group Coordinator of this site? Confirm its status | Beverly Hills | United States | Unknown status |
| Envision Ocular, LLC Coordinator of this site? Confirm its status | Bloomfield | United States | Unknown status |
| Ophthalmic Consultants of Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Cary | United States | Unknown status |
| Charleston Neuroscience Center Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Mid Atlantic Retina New Jersey Coordinator of this site? Confirm its status | Cherry Hill | United States | Unknown status |
| Retina Group of Washington Coordinator of this site? Confirm its status | Chevy Chase | United States | Unknown status |
| University Hospitals Cleveland Medical Center* Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Retina Consultants of Southern Colorado PC Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Retina Foundation of the Southwest Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Rand Eye Institute Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| RSC Research, LLC Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Retina Vitreous Center Coordinator of this site? Confirm its status | Edmond | United States | Unknown status |
| Retina Associates, Ltd. Coordinator of this site? Confirm its status | Elmhurst | United States | Unknown status |
| Erie Retina Research LLC Coordinator of this site? Confirm its status | Erie | United States | Unknown status |
| Verum Research, LLC Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| National Ophthalmic Research Institute Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Retinal Consultants of Orange County Clinical Research Institute Inc Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Global Research Management Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Mid Atlantic Retina Specialists Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Long Island Vitreoretinal Consultants Coordinator of this site? Confirm its status | Hauppauge | United States | Unknown status |
| Southeastern Retina Associates Coordinator of this site? Confirm its status | Johnson City | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Katy | United States | Unknown status |
| Eye Care Specialists Coordinator of this site? Confirm its status | Kingston | United States | Unknown status |
| Piedmont Eye Center Coordinator of this site? Confirm its status | Lynchburg | United States | Unknown status |
| Georgia Retina PC Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
| Retina Consultants Medical Group Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Northern California Retina Vitreous Associates Medical Group INC. Coordinator of this site? Confirm its status | Mountain View | United States | Unknown status |
| Tennessee Retina, PC Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| University Retina Coordinator of this site? Confirm its status | Oak Forest | United States | Unknown status |
| Florida Retina Institute Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Fort Lauderdale Eye Institute Coordinator of this site? Confirm its status | Plantation | United States | Unknown status |
| Eyehealth Northwest Portland Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Maine Eye Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Sierra Eye Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Retinal Consultants Medical Group Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Retina Consultants of Minnesota Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Rocky Mountain Retina Consultants Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Retina Consultants of Texas: San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Group of Florida Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Retina Macula Institute of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| Retina Research Institute at New England Retina Consultants Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Cascade Medical Research Institute Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Clinic, LLP Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| East Florida Eye Institute Coordinator of this site? Confirm its status | Stuart | United States | Unknown status |
| Retina Associates of Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Macula Retina Vitreous Research Institute Coordinator of this site? Confirm its status | Torrance | United States | Unknown status |
| Tulsa Retina Consultants Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Wake Forest | United States | Unknown status |
| Bay Area Retina Associates Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Eye Clinic of Wisconsin Coordinator of this site? Confirm its status | Wausau | United States | Unknown status |
| Wolfe Eye Clinic Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Strategic Clinical Research Group, LLC Coordinator of this site? Confirm its status | Willow Park | United States | Unknown status |
| Piedmont Retina Specialists Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.