NCT06511310Recruiting
Exercise, Brain Activity, and Weight Maintenance
Effects of Exercise Training on Brain Activity and Its Relation to Weight Maintenance and Appetite Regulation
Source: ClinicalTrials.gov · Last updated 4 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 18 Jun 2024
- Start date
- 15 Sept 2025
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Joslin Diabetes Center
- Diseases
- Obesity
- NCT number
- NCT06511310
What you commit to
- Study type: Interventional
- Planned participants: 15
- From 15 Sept 2025 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Type 1 diabetes mellitus
- Active Heart or lung disease
- Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
- MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
- History of cardiovascular disease, stroke, congestive heart failure
- Active hematological, renal, pulmonary or hepatic disorders
- Active treatment for cancer
- A history of active alcohol or substance abuse
- Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
- History of claustrophobia and inability to tolerate an MRI
Other
- Peripheral neuropathy with insensate feet
- Recent blood donation within the last 2 months
- Use of beta-blockers
- Current pregnancy or breastfeeding
- Inability to exercise for any reason
- Any known contraindication to exercise testing based on current ACSM guidelines
- Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
- Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
- Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
- Left-handedness
Who the study is looking for
- Age 18-70 years
- Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
- Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
- In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
- Willing to adhere to the protocol requirements for the duration of the study
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Joslin Diabetes Center Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.