NCT06512623Completed
Cytokine Adsorption During Complex Cardiac Surgery: a Controlled Randomized Trial
Cytokine Adsorption During Complex Cardiac Surgery: the JACCS Controlled Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 23 Jan 2026
Brief summary (registry, in English)
This prospective single-centre randomized controlled trial aims at evaluating the safety and efficacy of hemoadsorption with HA-380® during cardio-pulmonary bypass in 40 patients undergoing complex cardiac surgery.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 41 (actual)
- First submitted
- 1 Jul 2024
- Start date
- 27 Oct 2024
- Primary completion date
- 18 Dec 2025
- Lead sponsor
- Centre Hospitalier Universitaire Vaudois
- NCT number
- NCT06512623
What you commit to
- Study type: Interventional
- Participants enrolled: 41
- From 27 Oct 2024 to the primary completion date, 18 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Indication to receive hemoadsorption during CPB for drugs removal
- Previous enrolment into the current study
- Participation in another study with investigational drug within the 30 days preceding and during the present study
Other illness
- Known allergy to heparin or heparin induced thrombocytopenia
Lab values
- Severe thrombopenia (platelets count before surgery \< 20g/L)
Other
- Women who are pregnant or breastfeeding
- Off-pump procedure
- Chronic immunosuppression
- Patient who does not want to be informed of incidental findings
- Participation in another conflicting research study
Who the study is looking for
- Adults (≥18 years old at study inclusion)
- Planned for one of the following cardiac surgical procedures: heart transplantation after L-VAD (left ventricular assist device) implantation, OR surgical repair of a type A aortic dissection, OR urgent (within a few days) or emergent (within 24 hours) procedure for acute infectious endocarditis, OR cardiac surgery likely to require \>180 min CPB time as estimated by the surgical team
- Signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Universitaire Vaudois Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.