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NCT06512831Completed

Isoniazid Prophylaxis Based on Risk Factors of Tuberculosis in Living Kidney Transplantation Recipients

Isoniazid Prophylaxis Based on Risk Factors of Tuberculosis in Living Kidney Transplantation Recipients: A Retrospective Cohort Study

Source: ClinicalTrials.gov · Last updated 22 Jul 2024

Brief summary (registry, in English)

Tuberculosis (TB) is a major and severe opportunistic infection among solid organ transplant recipients. Chemoprophylaxis is advised for those with latent tuberculosis infection (LTBI). However, the effectiveness of an isoniazid (INH) prophylactic approach based on TB risk factors, without relying on tuberculin skin test (TST) or interferon-gamma release assay (IGRA), remains uncertain. Therefore, the investigators conducted this retrospective study to evaluate the safety and efficacy of a 6-month INH prophylaxis regimen guided by TB risk factors in kidney transplant recipients.

Status (registry)
Completed
Study type
Interventional
Enrollment
1348 (actual)
First submitted
14 Jul 2024
Start date
1 Jun 2023
Primary completion date
1 Feb 2024
Lead sponsor
West China Hospital
Diseases
Tuberculosis
NCT number
NCT06512831

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1348
  • From 1 Jun 2023 to the primary completion date, 1 Feb 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • multiorgan transplantation
  • those who had received a nine-month course of INH.

Other illness

  • active TB infection
  • malignancy history in the donor and recipient
  • human immunodeficiency virus infection

Other

  • liver cirrhosis

Who the study is looking for

  • living-donor kidney transplant recipients
  • receiving standard triad immunosuppressive regimen

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
West China Hospital,Sichuan University
Coordinator of this site? Confirm its status
ChengduChinaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.