NCT06514794RecruitingPhase 2
A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)
A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in Patients With Relapsed/Refractory Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-RRex)
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The T-RRex study evaluates the efficacy of WU-CART-007 for patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL) and to WU-CART-007 as a therapy to induce complete Minimum Residual Disease (MRD) negative response
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 125 (estimated)
- First submitted
- 17 Jul 2024
- Start date
- 31 Jan 2025
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- Allotera Therapeutics
- NCT number
- NCT06514794
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 125
- From 31 Jan 2025 to the primary completion date, 30 Dec 2026
- 18 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with any anti-CD7 therapy.
- Presence of Grade 2 to 4 acute or extensive chronic GvHD requiring systemic immunosuppression. Grade 1 GvHD not requiring immunosuppression or Grade 2 skin GvHD if treated with topical therapy only are acceptable.
Other
- Patients with decompensated hemolytic anemia.
Who the study is looking for
- Disease Criteria: Evidence of T-ALL or T-LBL, as defined by World Health Organization (WHO) classification, and either relapse/refractory or MRD positive
- Age: Lower age limit of ≥ 6 months; adequate organ function
- Eastern Cooperative Oncology Group (ECOG) 0 or 1/Karnofsky Performance Status 70 and above at Screening.
Age in the registry: 6 months to - · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peter Mac Callum Cancer Institute Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Royal Children's Melbourne Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Children's Hospital of Atlanta Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Cincinnati Children's Hospital Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Oncology Hematology Care Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Colorado Blood Cancer Institute Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Children's Hospital Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| TriStar Bone Marrow Transplant / Sarah Cannon Transplant & Cellular Therapy Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Memorial Sloan Kettering Cancer Center -- Pediatrics Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Sarah Cannon, Virginia Oncology Associates Coordinator of this site? Confirm its status | Norfolk | United States | Recruiting |
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Sarah Cannon Transplant and Cellular Therapy Methodist Hospital Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| Seattle Children's Hospital Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Washington University Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| H. Lee Moffitt Cancer Center and Research Institute Hospital Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Children's National Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.