NCT06515054Completed
Isometric Exercise for Hypertension
Effectiveness and Mechanisms of Isometric Resistance Exercise to Reduce Blood Pressure in a Chinese Population: a Pilot Randomized-controlled Trial
Source: ClinicalTrials.gov · Last updated 16 Dec 2025
Brief summary (registry, in English)
Background: Isometric resistance exercises (IREs) have great potential to improve blood pressure (BP) control. Methods: This is a pilot randomized controlled trial that will involve 50 patients with hypertension (HT) who do not meet the current physical activity guidelines defined by the World Health Organization. Participants will be randomly assigned in a 1:1 ratio using stratified and blocked randomization to either the IRE (wall squat) group or stretching exercise (active control) group. A well-structured, widely accepted, and validated 24-week wall squat program (2 minutes per exercise, 2 minutes of rest between sets, and 3 sessions per week) will be implemented, as it has been commonly used in previous research. All patients will be followed up for 24 weeks. Control group will receive exact same treatment except that IRE is replaced by frequency-matched and time-matched stretching exercise. The primary outcome measure will be rate of recruitment. Secondary outcomes will include BP parameters from 24-hour ambulatory BP monitoring
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 50 (actual)
- First submitted
- 15 Jul 2024
- Start date
- 20 Jul 2024
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- Chinese University of Hong Kong
- Diseases
- High blood pressure
- NCT number
- NCT06515054
What you commit to
- Study type: Interventional
- Participants enrolled: 50
- From 20 Jul 2024 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- severe osteoarthritis pending knee replacement surgery
- use of ≥3 anti-HT medications at maximum doses or ≥4 anti-HT medications
Other illness
- relative contraindications to ABPM (i.e. diagnosed atrial fibrillation, nighttime workers, occupational drivers, or patients with bleeding tendencies)
- active malignancy
Other
- cannot provide informed consent
- unwillingness to repeat ABPM
- known secondary HT
- SBP or DBP are \>160 mmHg or \>100 mmHg, respectively, on ABPM
- pregnancy/breastfeeding
Who the study is looking for
- a suboptimal daytime SBP of \>135-160 mmHg on a 24-h ABPM
- reported no regular physical activity or less than that recommended for adults by the World Health Organization (e.g. \<150 minutes of moderate-intensity aerobic exercise per week);
- on stable doses of anti-HT medication(s) for ≥4 weeks if the patient is receiving drug treatments
- agree for no drug changes during the intervention period (24 weeks);
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| School of public health and primary care Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.