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NCT06515613RecruitingPhase 1

A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

A Phase 1, First in Human Study of CTIM-76, a Claudin-6 (CLDN6)-Directed Bispecific Antibody, in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

Source: ClinicalTrials.gov · Last updated 3 Sept 2026

Brief summary (registry, in English)

This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and efficacy of CTIM-76 (study drug), a CLDN6-directed T cell-engaging bispecific antibody , in participants with platinum-refractory/resistant ovarian cancer (PRROC) and other advanced CLDN6-positive solid tumors (i.e., testicular and endometrial).

Status (registry)
Recruiting
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
156 (estimated)
First submitted
16 Jul 2024
Start date
10 Jul 2024
Primary completion date
31 May 2028
Lead sponsor
Context Therapeutics Inc.
NCT number
NCT06515613
EU CT number
2025-523968-20-00

What you commit to

  • Study type: Interventional · Phase 1
  • Planned participants: 156
  • From 10 Jul 2024 to the primary completion date, 31 May 2028
  • 24 sites in 4 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Concurrent participation in another investigational clinical trial.

Other illness

  • Evidence of central nervous system metastases, leptomeningeal disease or spinal cord compression.
  • Uncontrolled significant active infection or any medical or other condition that in opinion of the Investigator would preclude the participant's participation in the study.

Who the study is looking for

  • Participants with CLDN6 positive platinum resistant/refractory ovarian, advanced testicular or advanced endometrial cancer.
  • Participants with measurable disease per RECIST 1.1.
  • ECOG 0, 1, or 2 and life expectancy of ≥ 12 weeks.
  • Participants with adequate organ function.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (24)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hospital Universitari Vall d'Hebron
Coordinator of this site? Confirm its status
BarcelonaSpainNot yet recruiting
Hospital Universitario Fundación Jiménez Díaz
Coordinator of this site? Confirm its status
MadridSpainNot yet recruiting
Hospital Universitario 12 de Octubre
Coordinator of this site? Confirm its status
MadridSpainNot yet recruiting
Centre Leon Berard
Coordinator of this site? Confirm its status
LyonFranceNot yet recruiting
Centre Antoine Lacassagne
Coordinator of this site? Confirm its status
Nice Cedex 2FranceNot yet recruiting
Centre De Lutte Contre Le Cancer Eugene Marquis
Coordinator of this site? Confirm its status
Rennes CedexFranceNot yet recruiting
Institut De Cancerologie De L Ouest
Coordinator of this site? Confirm its status
Saint-Herblain CedexFranceNot yet recruiting
Les Hopitaux Universitaires De Strasbourg
Coordinator of this site? Confirm its status
Strasbourg Cedex 2FranceNot yet recruiting
Institut Gustave Roussy
Coordinator of this site? Confirm its status
VillejuifFranceNot yet recruiting
University College London Hospital
Coordinator of this site? Confirm its status
LondonUnited KingdomRecruiting
Precision NextGen Oncology & Research Center
Coordinator of this site? Confirm its status
Beverly HillsUnited StatesWithdrawn
Dana-Farber Cancer Institute
Coordinator of this site? Confirm its status
BostonUnited StatesRecruiting
Gabrail Cancer Center
Coordinator of this site? Confirm its status
CantonUnited StatesWithdrawn
SCRI at Mary Crowley
Coordinator of this site? Confirm its status
DallasUnited StatesRecruiting
SCRI at Denver Health
Coordinator of this site? Confirm its status
DenverUnited StatesRecruiting
Duke Cancer Institute
Coordinator of this site? Confirm its status
DurhamUnited StatesRecruiting
John Theurer Cancer Center
Coordinator of this site? Confirm its status
HackensackUnited StatesTerminated
University of Arkansas - Winthrop P. Rockefeller Cancer Institute
Coordinator of this site? Confirm its status
Little RockUnited StatesRecruiting
Vanderbilt-Ingram Cancer Center
Coordinator of this site? Confirm its status
NashvilleUnited StatesRecruiting
Memorial Sloan-Kettering Cancer Center
Coordinator of this site? Confirm its status
New YorkUnited StatesRecruiting
University of Nebraska Medical
Coordinator of this site? Confirm its status
OmahaUnited StatesRecruiting
Fox Chase Cancer Center
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesWithdrawn
Providence Cancer Institute of Oregon
Coordinator of this site? Confirm its status
PortlandUnited StatesRecruiting
Women & Infants Hospital of Rhode Island
Coordinator of this site? Confirm its status
ProvidenceUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.