NCT06518642Completed
Transcranial Direct Current Stimulation (tDCS) in Young Individuals with Major Depressive Disorder: a Literature Review and Feasibility Study
Source: ClinicalTrials.gov · Last updated 27 Nov 2024
Brief summary (registry, in English)
Objectives: (1) To assess the therapeutic effects of tDCS on improving depressive symptoms in young individuals with Major Depressive Disorder (MDD), relative to sham stimulation ; and (2) to evaluate the tolerability, and feasibility of tDCS in young individuals with Major Depressive Disorder, to explore the feasibility for a scale-up study. Hypothesis: 1) we hypothesize the tDCS stimulation of the dorsolateral prefrontal cortex (dLPFC) will reduce symptoms of depression more than sham stimulation, demonstrated by significant difference in change of Hamilton Depression Rating Scale (HDRS) and 2) tDCS active stimulation of the dLPFC will be tolerable and feasible among patients with MDD, as demonstrated by minimal adverse effects measured in the Adverse Events Questionnaire, adherence (with reasons of drop out), their motivation and enjoyment to participate in the study .
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 8 (actual)
- First submitted
- 18 Jul 2024
- Start date
- 31 Jul 2024
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- The University of Hong Kong
- Diseases
- Depression
- NCT number
- NCT06518642
What you commit to
- Study type: Interventional
- Participants enrolled: 8
- From 31 Jul 2024 to the primary completion date, 31 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant unstable medical conditions; major neurological conditions;
Other illness
- History of significant head trauma, neurological disorders (e.g., epilepsy), seizures;
- First degree relative with epilepsy;
- Comorbid disorders listed in the DSM-V, e.g., schizophrenia, substance use disorder, mental retardation, etc.;
- Device or metal clips on or inside the skull, cardiac pacemaker;
Other
- Pregnancy, lactating women, or women planning pregnancy;
- Inability to provide informed consent.
Who the study is looking for
- Diagnosed with major depressive disorder (MDD) according to the Structured Clinical Interview for DSM-5, Clinical Version (SCID-DSM-5, CV)
- Scored ≥ 14 (i.e., at least mild to moderate depression on the 17-item Hamilton Depression Rating Scale (HDRS) at screening and at baseline;
- Right handedness;
- Stable dosage of antidepressants or other treatments for depression in recent 4 weeks; and
- Can read and write Chinese.
Age in the registry: 16 years to 25 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Hong Kong Coordinator of this site? Confirm its status | Hong Kong | Hong Kong | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.