Robot-Assisted vs. Video-Assisted Lobectomy for NSCLC (RAVAR)

Prior treatment

• Patients with radiotherapy, chemotherapy, targeted therapy, or immunotherapy before surgery.
• Patients diagnosed as pure ground glass opacity (GGO) before surgery;
• Patients with prior unilateral open thoracic surgical procedures;

Other illness

• Patients with the previous history of other malignancies;
• Patients with secondary primary cancer when enrolled;
• Patients with small cell lung cancer;
• Patients with an active bacterial or fungal infection that is difficult to control;
• Patients with a history of severe heart attack, heart failure, myocardial infarction, or angina within the last 6 months.

Other

• Patients diagnosed as mixed GGO whose solid part \<= 50% and Maximum diameter of tumor \<= 2cm;
• Woman who is pregnant or breastfeeding;
• Patients with interstitial pneumonia, pulmonary fibrosis, or severe emphysema;
• Patients with serious psychosis;

• Age from 18 to 80 years old;
• Patients with blood pressure\<160/100mmHg, 5.6\<blood glucose\<11.2mmol/L, major organs function normally: (1) Goldman index between grade 1 and 2; (2) Predicted forced expiratory volume in 1s (FEV1) \>= 40 % and diffusing capacity of the lung for carbon monoxide (DLCO) \>= 40 %; (3) total bilirubin \<= 1.5 upper limit of normal; (4) Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) \<= 2.5 upper limit of normal; (5) creatinine \<= 1.25 upper limit of normal and creatinine clearance rate (CCr) \>= 60ml/min;
• The first clinical diagnosis before surgery was non-small cell lung cancer, including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and other unknown types;
• Clinical stage T1-2N0-1 (cI-II): Maximum diameter of tumor \<= 5cm and short diameter of mediastinal lymph node \<= 1cm in thin layer CT;
• Performance status of Eastern Cooperative Oncology Group (ECOG) 0-1;
• All relevant examinations were completed within 28 days before the operation;
• Patients who understand this study and have signed an approved Informed Consent.