NCT06525116Completed
MRD Detection by NGS in Pediatric T-ALL
Measurable Residual Disease Detection by Next-generation Sequencing of T Cell Receptor Gene Rearrangements in Pediatric T-cell Acute Lymphocytic Leukemia
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
This retrospective analysis aims to investigate pediatric patients with T cell acute lymphoblastic leukemia who were detected for minimal residual disease (MRD) using next-generation sequencing (NGS). The study will utilize second-generation sequencing technology to analyze the rearrangement of the T cell receptor (TCR) genes in these patients. Patients will be stratified based on NGS-MRD levels, and the relationship between NGS MRD and Event-Free Survival (EFS) will be evaluated.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 148 (actual)
- First submitted
- 24 Jul 2024
- Start date
- 1 Feb 2018
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- The Children's Hospital of Zhejiang University School of Medicine
- NCT number
- NCT06525116
What you commit to
- Study type: Observational
- Participants enrolled: 148
- From 1 Feb 2018 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- T-ALL patients who have not undergone high-throughput sequencing.
- T-ALL Patients without traceable significant clones.
Who the study is looking for
- Children with newly diagnosed T-ALL who undergone NGS of T-cell receptors
Age in the registry: 1 year to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Children's Hospital of Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.