NCT06526429Completed
Local Ischemic Postconditioning in Acute Ischemic Stroke
RAPID Local Ischemic Postconditioning in Acute Ischemic Stroke pAtients receiVEd Successful Thrombectomy Reperfusion
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
This study aims to determine the safety and optimal dose of rapid local ischemic postconditioning in acute ischemic stroke(AIS) patients received successful thrombectomy reperfusion. In this trial, investigators will halt antegrade cerebral blood flow temporarily by the way of balloon guiding catheter (BGC) inflation/deflation in AIS patients immediately after revascularization. It makes the ischemic reperfusion brain tissue have a capacity of adaptation through intermittent blood flow restoration. The optimal postconditioning intervention dose will be determined for further investigation.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 25 (actual)
- First submitted
- 24 Jul 2024
- Start date
- 14 Oct 2024
- Primary completion date
- 4 Jul 2025
- Lead sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- Diseases
- Stroke
- NCT number
- NCT06526429
What you commit to
- Study type: Interventional
- Participants enrolled: 25
- From 14 Oct 2024 to the primary completion date, 4 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Pre ischemic stroke within past 3 months
- The expected survival time is less than 6 months, could not be followed at 90 days (such as patient with malignant tumor)
- Currently pregnant, mental disease, advanced hepatic and renal insufficiency, severe heart failure
Other
- Stenosis of the proximal middle cerebral artery, internal carotid artery, or common carotid artery (≥50%) of the culprit artery
- Evidence of internal carotid artery lesion that precludes the access and application of balloon guide catheter
- Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or an MCA and a basilar artery occlusion)
- Participation in other interventional randomized clinical trials that may confound the outcome assessment of the trial
- Other circumstances that the investigator considers inappropriate for this trial
Who the study is looking for
- Age ≥ 18 years old
- Presenting with symptoms and signs consistent with acute anterior circulation ischemic stroke
- Pre-stroke modified Rankin Score 0-1
- Baseline National Institute of Health Stroke Scale (NIHSS) score≥6
- Endovascular treatment can be initiated (femoral puncture) within 24 hours from stroke onset (stroke onset time is defined as last known well time)
- Occlusion of the intracranial internal carotid artery, or the middle cerebral artery (MCA) (M1 or M2) and is the culprit artery
- Ischemic core volume is \< 70 ml, mismatch ratio is \>1.8 and mismatch volume is \>15 ml as determined by CT perfusion imaging
- Embolism verified as the etiology of occluded artery and modified Thrombolysis in Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy.
- Time from CT perfusion to reperfusion \< 2 hours
- Informed consent signed
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Jiao Tong University Affiliated Sixth People's Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.