NCT06526702Completed
Intradialytic Kinetics of Cardiac Biomarkers During Hemodialysis and Hemodiafiltration
Source: ClinicalTrials.gov · Last updated 7 Oct 2025
Brief summary (registry, in English)
This randomized, crossover study aims to investigate the intradialytic kinetics of selected cardiac biomarkers in patients with end-stage renal disease treated with dialysis. The cardiac biomarkers of interest include high-sensitivity cardiac troponin I, high-sensitivity cardiac troponin T, brain natriuretic peptide, and a novel cardiac biomarker named secretoneurin. In 24 patients treated with maintenance hemodialysis, the study will compare high-flux hemodialysis (HD) with post-dilution hemodiafiltration (HDF) to investigate: * Baseline concentrations and week-to-week plasma variations of the cardiac biomarkers. * Changes in the plasma concentrations of the cardiac biomarkers during high-flux HD and post-dilution HDF. * Dialyzer clearance of the cardiac biomarkers in high-flux HD and post-dilution HDF. * Adherence of the cardiac biomarkers to the dialyzer membrane. * Concentrations of the cardiac biomarkers 30 minutes post-dialysis to investigate a potential rebound effect. Additionally, a sub-study of 24 patients treated with peritoneal dialysis will investigate the baseline concentrations and week-to-week plasma variations of the same cardiac biomarkers.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 24 Jul 2024
- Start date
- 12 Sept 2024
- Primary completion date
- 10 Apr 2025
- Lead sponsor
- Aalborg University Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT06526702
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 12 Sept 2024 to the primary completion date, 10 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \- Not able to understand or sign informed consent.
Who the study is looking for
- Age of 18 years or older.
- Clinically stable patients with end-stage renal disease treated with maintenance hemodialysis or peritoneal dialysis.
- Regarding patients treated with hemodialysis: Dialysis access with an arteriovenous fistula and able to maintain a blood flow rate \>300 mL.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Nephrology, Aalborg University Hospital Coordinator of this site? Confirm its status | Aalborg | Denmark | Unknown status |
Related publications
- Intradialytic Kinetics of Cardiac Biomarkers during High-Flux Hemodialysis and Postdilution Hemodiafiltration: A Randomized Crossover Trial.Kidney360 · 2026 · PMID 42475358
- Intradialytic kinetics of cardiac biomarkers during high-flux haemodialysis and postdilution haemodiafiltration: study protocol for a randomised crossover trial.BMJ Open · 2026 · PMID 41545041
This page is information, not medical advice. Discuss any trial with your doctor.