NCT06528353Not yet recruiting
Blood Biomarkers Based Screening for HPV-driven OPC
SCREEN-HPV: Blood Biomarkers Based Screening for HPV-driven OPC
Source: ClinicalTrials.gov · Last updated 26 May 2026
Brief summary (registry, in English)
The objective of our study is to demonstrate that it is possible to detect and treat human papilloma virus (HPV)-related oropharyngeal cancers (OPC) early using simple blood tests. The success of this strategy will be evaluated by the number of participants positive for both HPV16-E6 serology and HPV circulating tumor DNA (ctDNA) whose early management has allowed the detection of a cancerous lesion and/or whose HPV ctDNA results have normalized after surgical intervention. If this study is conclusive, it could pave the way for the implementation of a national screening strategy for HPV-related OPC.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 10000 (estimated)
- First submitted
- 25 Jul 2024
- Start date
- Sept 2026
- Primary completion date
- Sept 2032
- Lead sponsor
- UNICANCER
- Diseases
- Head and neck cancer
- NCT number
- NCT06528353
What you commit to
- Study type: Interventional
- Planned participants: 10000
- From Sept 2026 to the primary completion date, Sept 2032
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous prophylactic HPV vaccination
Other illness
- History of HPV-driven cancer or head and neck cancer
- Psychiatric conditions
Age
- Aged \< 50 years
- Severe medical condition (life expectancy \<5 years)
Other
- Woman
- Inability to complete follow up visits
Who the study is looking for
- Aged ≥50 years from the general population
- Man
- No previous history of HPV-driven cancer or head neck cancer
- Willingness to complete follow up visits
Age in the registry: 50 years to - · Sex: Male · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.