NCT06529848Recruiting
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Ischemia With No Obstruction of Coronary Arteries: Underlying Mechanisms and the Impact of Exercise Training (EXINOCA)
Source: ClinicalTrials.gov · Last updated 21 Feb 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function. Hypotheses: The first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body. The second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 4 Jul 2024
- Start date
- 1 Nov 2024
- Primary completion date
- 30 Oct 2027
- Lead sponsor
- Bispebjerg Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06529848
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Nov 2024 to the primary completion date, 30 Oct 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled hypertension defined as blood pressure above target 140/90 for all
Lab values
- Heart failure, defined as left ventricular ejection fraction of less than 40%
Other
- Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile
- Co-morbidity resulting in \<1 year expected survival
- Considered by the investigator, for any reason, to be an un-suitable candidate for the study.
- Unable or unwilling to exercise, e.g. due to arthritis or in-jury\*
- Already are regularly physically active and/or have a maxi-mal oxygen uptake \>45 ml/kg/min
Who the study is looking for
- Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) \< 2.5 or hyperemic myocar-dial blood flow (hMBF)\<2.3 ml/g/min using \[15O\]H2O-PET
- No obstructive coronary artery disease
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000 Coordinator of this site? Confirm its status | Copenhagen | Denmark | Not yet recruiting |
| Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57 Coordinator of this site? Confirm its status | Frederiksberg | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.