NCT06531434RecruitingPhase 1/2
Establishing Best Treatment Strategy for T4 Esophageal Cancer
A Pilot Study to Establish Best Treatment Strategy for T4 Esophageal Cancer
Source: ClinicalTrials.gov · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy. The main questions it aims to answer are: * Does the new induction chemotherapy followed by chemoradiation reduce esophageal perforation rate? * Does the new induction chemotherapy followed by chemoradiation increase treatment response rate and patient survival? Researchers will analyze the above data to see if the new treatment approach works to treat T4 esophageal cancer. Participants will: * Receive induction chemotherapy for 4 to 8 cycles, followed by chemoradiation therapy if downstage to T3 * Visit the clinic once every week for checkups and tests * Keep a diary of their symptoms
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 22 (estimated)
- First submitted
- 16 Jul 2024
- Start date
- 1 Aug 2024
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- National Cheng-Kung University Hospital
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT06531434
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 22
- From 1 Aug 2024 to the primary completion date, 30 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous chemotherapy history
Other illness
- Myocardial infarction within the last three months
- History of unstable angina, interstitial pneumonia, fibrotic lung disease, or severe emphysema
- Has other malignancies currently
- Uncontrolled infection
Other
- Pregnancy or lactation
- Perforated esophagus at the time of diagnosis
Who the study is looking for
- Histologically confirmed esophageal squamous cell carcinoma
- Tumor or lymph nodes invade adjacent organs (T4 stage)
- Aged between 18-70 years old
- Patient health status score Eastern Cooperative Oncology Group (ECOG) performance status (PS) \<2
- Hemoglobin ≥ 10 g/L, absolute neutrophil count ≥ 2×10\^3/L, platelet count ≥ 100×10\^9/L, total bilirubin ≤ 1.5 mg/L, serum transaminases ≤ 105 U/L, creatinine clearance ≥ 40 mL/min.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Cheng Kung University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.