NCT06533930Completed
Evaluation of the Relationship Between Optic Nerve Diameter and Optic Nerve Sheath Diameter Measured by Transorbital Sonography With Clinical, Radiological, and Electrophysiological Parameters in Multiple Sclerosis Patients
Source: ClinicalTrials.gov · Last updated 29 Aug 2025
Brief summary (registry, in English)
The primary aim of this study is to evaluate the reliability of optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) measurements made with transorbital sonography (TOS) and magnetic resonance imaging (MRI) in patient groups that may progress with subclinical optic atrophy over time, such as those with multiple sclerosis (MS). The secondary aims of this study are to compare the relationship of TOS with visual evoked potentials (VEP) and optical coherence tomography (OCT) parameters used in the assessment of the afferent visual pathway in MS and its clinical subtypes and to evaluate the potential of TOS as a diagnostic and monitoring tool for detecting optic nerve atrophy, subclinical axonal loss, and clinical disability in MS.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 136 (actual)
- First submitted
- 30 Jul 2024
- Start date
- 1 Oct 2023
- Primary completion date
- 1 Apr 2024
- Lead sponsor
- Kutahya Health Sciences University
- Diseases
- Multiple sclerosis
- NCT number
- NCT06533930
What you commit to
- Study type: Observational
- Participants enrolled: 136
- From 1 Oct 2023 to the primary completion date, 1 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Having ocular pathology that may affect optic nerve measurements (e.g., glaucoma, high myopia, history of ocular surgery)
- Having major systemic diseases that may affect optic nerve measurements (e.g., diabetes mellitus, hypertension)
Other
- Patients whose Multiple Sclerosis diagnosis is uncertain
- EDSS score \> 7
- Having experienced a clinical relapse or optic neuritis within the last 6 months.
Who the study is looking for
- Being between the ages of 18-65
- Having been diagnosed with Multiple Sclerosis
- Undergoing disease-modifying therapy (DMT) for more than 6 months
- EDSS score ≤ 7
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kutahya Health Sciences University, Faculty of Medicine Coordinator of this site? Confirm its status | Kütahya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.